25236-64-0

Basic information

• Product Name: 2,2,2-TRIFLUOROETHYL METHANESULFONATE
• Synonyms: 2,2,2-Trifluoroethyl methanesulfonate >=98.0% (GC);2,2,2-Trifluoro-ethanol 1-methanesulfonate;METHANESULFONIC ACID 2,2,2-TRIFLUOROETHYL ESTER;2,2,2-TRIFLUOROMETHYL MESYLATE;2,2,2-TRIFLUOROETHYL METHANESULFONATE;2,2,2-TRIFLUOROETHYL METHANESULPHONATE;2,2,2-Trifluoroethyl methanesulphonate 98%;2,2,2-Trifluoroethylmethanesulphonate98%
• CAS NO: 25236-64-0
• Molecular Formula: C₃H₅F₃O₃S
• Molecular Weight: 178.13
• Product Categories: Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Small molecule
• Mol File: 25236-64-0.mol

Chemical Properties

• Boiling Point: 99 °C / 35mmHg
• Flash Point: 103°C
• Appearance: /
• Density: 1.513 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: n20/D 1.367
• BRN: 1863049
• CAS DataBase Reference: 2,2,2-TRIFLUOROETHYL METHANESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUOROETHYL METHANESULFONATE(25236-64-0)
• EPA Substance Registry System: 2,2,2-TRIFLUOROETHYL METHANESULFONATE(25236-64-0)

Safety Data

• Hazard Codes: C
• Statements: 34-35
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• F: 10-21
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 25236-64-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C12H11F3O4/c1-2-18-11(17)7-10(16)8-3-5-9(6-4-8)19-12(13,14)15/h3-6H,2,7H2,1H3

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 124-63-0 methanesulfonyl chloride 
• 338741-98-3 C₁₃H₁₉NO₄S 

Downstream Products

• 90633-29-7 1-(2,2,2-trifluoroethyl)piperidin-4-ol 
• 766-92-7 [(methylthio)methyl]-benzene 
• 77745-03-0 2,2,2-trifluoroethylthiomethylbenzene 
• 76579-44-7 1-(4-(2,2,2-trifluoroethoxy)phenyl)ethan-1-one 
• 103-50-4 dibenzyl ether 
• 67696-28-0 ((2,2,2-trifluoroethoxy)methyl)benzene 
• 62158-88-7 1-(2,2,2-trifluoroethoxy)-4-methoxybenzene 
• 19013-30-0 p-methoxyphenyl mesylate 
• 76579-47-0 3-Methoxy-4-(2,2,2-trifluoro-ethoxy)-benzaldehyde 
• 76579-46-9 4-(2,2,2-trifluoroethoxy)benzaldehyde 
• 115-10-6 Dimethyl ether 
• 76579-45-8 4-((trifluoro)ethoxy)phenyl acetate 
• 62149-35-3 1-(2,2,2-trifluoroethoxy)-4-nitrobenzene 
• 530-48-3 1,1-Diphenylethylene 

Relevant articles and documents

Chemical modification of poly(vinylacetylene) and synthesis of poly(1,2,3-triazole)s

A series of new polymers containing 1,2,3-triazoles were synthesized and their structures and properties were characterized by FT-IR, 1H NMR, TGA, DSC and GPC. The results showed that the polymers modified by alkyl groups had good solubility, thermal stability and reasonable molecular weights. It was also demonstrated that the properties of fluorine-containing polymers were seriously affected by fluorine atoms with hydrophobic and chemical proof properties.

Catalytic mesylation of alcohols: A highly productive process for trifluoroethyl mesylate

"Intermediate" Lewis acids are efficient catalysts for mesylation of trifluoroethanol (TFE) by mesyl chloride at 80 °C. In the absence of solvent, trifluoroethyl mesylate (TFEMes) is obtained in a chemical yield of 98% with total conversion of TFE. The only coproduct of the reaction, hydrochloric acid, simply distills from the reaction mixture. Distillation of TFEMes allows for recycle of the catalyst without any treatment.

Olefination with Sulfonyl Halides and Esters: Scope, Limitations, and Mechanistic Studies of the Hawkins Reaction

Carbanions of alkanesulfonyl halides and esters react with nonenolizable carbonyl compounds to give olefins. Mechanistic studies reveal that initial aldol-type addition of the carbanions is followed by cyclization-fragmentation to alkenes, and the leaving group on the sulfonyl moiety (RSO2X) controls carbanion stability and rate of the olefin formation.

DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5- AMINE

The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

ADRENERGIC RECEPTOR ANTAGONISTS

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A method of hydroxylation org. compd. sulfonylated

The invention concerns a method for sulphonylating a hydroxylated organic compound. The invention concerns in particular aliphatic hydroxylated compounds and more particularly those which comprise on their aliphatic chain, an electroattractive group. The

Method for sulphonylating a hydroxylated organic compound

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Pharmaceutical use of N-Carbamoylazole derivatives

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Electronic properties of the nitrone substituent. Stabilization of benzylic carbocations

The nitrone substituent CH=N(O) t-Bu is electron-withdrawing with a Taft σI value of 0.20. It also retards the solvolysis rate of a cumyl chloride when placed in the meta-position (σ = 0.20). However, CH=N(O) t-Bu becomes weakly cation stabilizing when placed in the para-position of a cumyl cation (σ+ = -0.04). This weak cation stabilization is a result of a conjugative interaction which delocalizes charge and offsets the inductive effect of the nitrone. When the nitrone is placed in the para-position, but then twisted out of conjugation with the aromatic ring by incorporation of flanking 3,5-dimethyl groups, it again retards solvolysis rates. Computational studies (B3LYP/6-31G*) show that the nitrone substituent stabilizes a para-substituted benzyl cation relative to the meta-substituted analog by a conjugative interaction. However, the calculated stabilization greatly overestimates the cation stabilization seen in solvolytic reactions. Copyright