6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester

Base Information

Chemical Name:6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester
CAS No.:81087-60-7
Molecular Formula:C24H28ClN3O4
Molecular Weight:457.9498
Hs Code.:
DSSTox Substance ID:DTXSID00230885
Nikkaji Number:J415.855E
Wikidata:Q83111638

6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester

Synonyms:3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-(3-(dimethylamino)propyl)-2,4(1H,3H)quinoline;6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester;81087-60-7;C24H28ClN3O4;SCHEMBL11023339;DTXSID00230885;C24-H28-Cl-N3-O4;LS-140055;1,2,3,4-Tetrahydro-3-(2-chlorophenyl)-1-(3-dimethylaminopropyl)-5,7-dimethyl-2,4-dioxoquinazoline-6-carboxylic acid ethyl ester

Suppliers and Price of 6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester

Chemical Property:

Vapor Pressure:4.74E-14mmHg at 25°C
Boiling Point:593.4°C at 760 mmHg
Flash Point:312.7°C
Density:1.241g/cm³
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:457.1768341
Heavy Atom Count:32
Complexity:703

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(C2=C(C=C1C)N(C(=O)N(C2=O)C3=CC=CC=C3Cl)CCCN(C)C)C

Technology Process of 6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester

There total 5 articles about 6-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(2-chlorophenyl)-5,7-dimethyl-1-(3-(dimethylamino)propyl)-2,4-dioxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 81087-60-7
3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-[3-(N,N-dimethylamino)propyl]-2,4-(1H,3H)-quinazolinedione

Guidance literature:

Reference yield: 68.0%

: 81087-59-4
3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione

: 109-54-6
3-(Dimethylamino)propyl chloride

: 81087-60-7
3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-[3-(N,N-dimethylamino)propyl]-2,4-(1H,3H)-quinazolinedione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 140 ℃; for 3h;
DOI:10.1248/cpb.39.1753

Reference yield:

: 3320-83-0
o-chlorophenyl isocyanate

: 81087-60-7
3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-[3-(N,N-dimethylamino)propyl]-2,4-(1H,3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 14 h / Ambient temperature

2: conc. HCl / ethanol / 2 h / Heating

3: 68 percent / NaH / dimethylformamide / 3 h / 140 °C

With hydrogenchloride; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1753