(4-METHYL-THIAZOL-2-YL)-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: (4-METHYL-THIAZOL-2-YL)-ACETIC ACID ETHYL ESTER
• CAS No.: 51221-43-3
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.247
• Hs Code.: 2934100090
• Mol file: 51221-43-3.mol

Synonyms:Ethyl4-methylthiazole-2-acetate

Chemical Property of (4-METHYL-THIAZOL-2-YL)-ACETIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0109mmHg at 25°C
• Boiling Point: 262.5°Cat760mmHg
• Flash Point: 112.6°C
• PSA: 67.43000
• Density: 1.174g/cm³
• LogP: 1.55710
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(4-Methyl-thiazol-2-yl)aceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (4-Methyl-thiazol-2-yl)acetic Acid Ethyl Ester is used as a reactant in the synthesis of polyfluoroalkylated pyrones, pyridones, and pyridobenzazoles.

Technology Process of (4-METHYL-THIAZOL-2-YL)-ACETIC ACID ETHYL ESTER

There total 3 articles about (4-METHYL-THIAZOL-2-YL)-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

ethoxycarbonylthioacetamide (13621-50-6) + chloroacetone (78-95-5) → ethyl (4-methyl-1,3-thiazol-2-yl)acetate (51221-43-3)

Guidance literature:

In N,N-dimethyl-formamide; at 105 ℃; for 15h;

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl (4-methyl-1,3-thiazol-2-yl)acetate (51221-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium ethylate; H₂S / -10 °C / Erwaermen in geschlossenem Gefaess auf 60-70grad

2: ethanol; diethyl ether

With diethyl ether; ethanol; hydrogen sulfide; potassium ethoxide;

DOI:10.1002/hlca.19480310519

Reference yield:

→ ethyl (4-methyl-1,3-thiazol-2-yl)acetate (51221-43-3)

Guidance literature:

upstream raw materials:

ethoxycarbonylthioacetamide

chloroacetone

ethyl 2-cyanoacetate

Downstream raw materials:

2-(4-methylthiazol-2-yl)acetic acid

2-(4-methyl-thiazol-2-yl)-acetamide

(4-methyl-thiazol-2-yl)-acetic acid hydrazide