13621-50-6

Basic information

• Product Name: ETHYL 3-AMINO-3-THIOXOPROPANOATE
• Synonyms: ETHYL 3-AMINO-3-THIOXOPROPANOATE;THIOCARBAMOYL ACETIC ACID ETHYL ESTER;THIOCARBAMOYL ACETIC ACID ETHYL ESTER ETHYL 3-AMINO-3-THIOXOPROPANOATE;(Ethoxycarbonyl)thioacetamide;alpha-Ethoxycarbonylthioacetamide;Ethyl thiocarbamoylacetate;Propanoic acid,3-amino-3-thioxo-, ethyl ester
• CAS NO: 13621-50-6
• Molecular Formula: C₅H₉NO₂S
• Molecular Weight: 147.2
• Mol File: 13621-50-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 78-79℃
• Boiling Point: 233℃
• Flash Point: 95℃
• Appearance: /
• Density: 1.194
• Vapor Pressure: 0.0586mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.71±0.29(Predicted)
• CAS DataBase Reference: ETHYL 3-AMINO-3-THIOXOPROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-AMINO-3-THIOXOPROPANOATE(13621-50-6)
• EPA Substance Registry System: ETHYL 3-AMINO-3-THIOXOPROPANOATE(13621-50-6)

Safety Data

• Hazardous Substances Data: 13621-50-6(Hazardous Substances Data)

Usage

General Description

Ethyl 3-amino-3-thioxopropanoate, also known as SDS 1:L31007, is a chemical compound with the molecular formula C6H11NO2S. Its systematic name is ethyl 3-amino-3-sulfanylpropanoate. It is known for its application in various areas of organic synthesis. The compound is notable for its suffocated and amino groups which contribute to its reactivity. This chemical is typically available in a solid form and should be handled and stored in accordance with relevant safety guidelines due to its potential reactivity and the risks associated with exposure.

InChI:InChI=1/C5H9NO2S/c1-2-8-5(7)3-4(6)9/h2-3H2,1H3,(H2,6,9)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 51221-43-3 ethyl (4-methyl-1,3-thiazol-2-yl)acetate 
• 7783-06-4 hydrogen sulfide 
• 365428-80-4 ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetate 
• 17969-11-8 [4-(4-bromo-phenyl)-thiazol-2-yl]-acetic acid ethyl ester 
• 28924-62-1 ethyl 1-(4-chlorophenyl)-5-amino-1H-1,2,3-triazole-4-carboxylate 
• 1421848-85-2 ethyl 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetate 
• 1441052-06-7 ethyl 3-thioxo-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxylate 
• 1403884-00-3 ethyl 2-bromo-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate 
• 17969-12-9 ethyl 2-(4-(4-chlorophenyl)thiazol-2-yl)acetate 
• 777839-19-7 ethyl [4-(4-methoxyphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]acetate 
• 796119-19-2 [4-(3-chloro-2-methoxy-5-triisopropylsilyloxy-phenyl)-thiazol-2-yl]-acetic acid ethyl ester 
• 139306-24-4 ethyl 2-(N,N'-dicyclohexyl-1-ethoxycarbonyl-4,6-dioxo-5,7-diazahept-2E-enylidene)-2,3-dihydro-5-methyl-6H,1,3-thiazine-4-carboxylate 

Relevant articles and documents

Thioacylation of CH-acid thioamides. 9. Thion- and dithioesters

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COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Substituted 1,3-thiazole compounds, their production and use

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.