6-Fluoro-6-deoxy-d-glucopyranose

Base Information

• Chemical Name: 6-Fluoro-6-deoxy-d-glucopyranose
• CAS No.: 447-25-6
• Molecular Formula: C₆H₁₁FO₅
• Molecular Weight: 182.149
• Hs Code.: 2940000080
• Mol file: 447-25-6.mol

Synonyms:6-Fluoro-6-deoxy-d-glucopyranose;34168-77-9;6-fluoro-6-deoxyglucose;(3R,4S,5S,6S)-6-(fluoromethyl)oxane-2,3,4,5-tetrol;(3R,4S,5S,6S)-6-(Fluoromethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol;SCHEMBL2952274;6-Deoxy-6-fluoro-glucopyranose;6-desoxy-6-fluoro-d-glucopyranose;MFCD00064096;AKOS006240258;CS-0362885;A822108;A826671;(2R,3R,4R,5S,6R)-6-(fluoromethyl)tetrahydropyran-2,3,4,5-tetrol;(3R,4S,5S,6S)-6-(fluoromethyl)tetrahydropyran-2,3,4,5-tetrol

Chemical Property of 6-Fluoro-6-deoxy-d-glucopyranose

Chemical Property:

• Vapor Pressure: 2.25E-10mmHg at 25°C
• Melting Point: 161-162
• Boiling Point: 354.6°Cat760mmHg
• Flash Point: 164.2°C
• PSA: 97.99000
• Density: 1.626g/cm³
• LogP: -2.40160
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly, Sonicated), Water (Slightly)
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 182.05905161
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

98%, ^*data from raw suppliers

6-Deoxy-6-fluoro-D-galactose ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)O)O)O)O)F
• Isomeric SMILES: C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)O)O)O)F
• Uses: 6-Deoxy-6-fluoro-D-galactose (cas# 447-25-6) is a compound useful in organic synthesis.

Technology Process of 6-Fluoro-6-deoxy-d-glucopyranose

There total 18 articles about 6-Fluoro-6-deoxy-d-glucopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 6-deoxy-6-fluoro-α-D-galactopyranoside (4536-13-4) → 6-deoxy-6-fluoro-D-galactopyranose (447-25-6,34168-77-9,62182-12-1,62182-13-2,143616-86-8,18961-68-7,502642-85-5)

Guidance literature:

With water; trifluoroacetic acid; at 100 ℃; for 5h;

DOI:10.1016/S0008-6215(99)00104-4

Reference yield: 75.0%

6-deoxy-6-fluoro-1,2:3,4-di-O-isopropylidene-α-D-galctopyranose (2021-97-8,6185-32-6,70981-54-3) → 6-deoxy-6-fluoro-D-galactopyranose (447-25-6,34168-77-9,62182-12-1,62182-13-2,143616-86-8,18961-68-7,502642-85-5)

Guidance literature:

With acetic acid; for 24h; Reflux;

Reference yield: 68.0%

1,2,3,4-di-O-isopropylidene-6-deoxy-6-fluoro-L-galactopyranoside → 6-fluoro-L-6-deoxy-galactose (447-25-6,18961-68-7,34168-77-9,62182-12-1,62182-13-2,143616-86-8,502642-85-5)

Guidance literature:

With acetic acid; In water;

DOI:10.1016/S0968-0896(00)00139-5

upstream raw materials:

6-deoxy-6-fluoro-1,2:3,4-di-O-isopropylidene-α-D-galctopyranose

methyl 6-deoxy-6-fluoro-α-D-galactopyranoside

methyl α-D-galactopyranoside

D-Galactose

Downstream raw materials:

1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-D-galactopyranose

1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-β-D-galactopyranose

1,2,3,4-tetra-O-benzoyl-6-deoxy-6-fluoro-L-galactopyranoside

dibenzylphosphoryl 2,3,4-tri-O-benzoyl-6-deoxy-6-fluoro-β-L-galactopyranoside