Cromakalim

Base Information

Chemical Name:Cromakalim
CAS No.:94470-67-4
Molecular Formula:C16H18N2O3
Molecular Weight:286.331
Hs Code.:
DSSTox Substance ID:DTXSID001017959,DTXSID301317350
Nikkaji Number:J386.542H
Wikipedia:Cromakalim
Wikidata:Q3698301
NCI Thesaurus Code:C79109
Pharos Ligand ID:8QA58TVYD56T
ChEMBL ID:CHEMBL11684
Mol file:94470-67-4.mol

Synonyms:BRL 38226;BRL 38227;BRL-34915;BRL-38226;BRL-38227;BRL38226;BRL38227;Cromakalim;Cromakalim, (3R-cis)-Isomer;Cromakalim, (3R-trans)-Isomer;Cromakalim, (3S-cis)-Isomer;Cromakalim, (3S-trans)-Isomer;Cromakalim, (trans)-Isomer;Lemakalim;Levcromakalim

Suppliers and Price of Cromakalim

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(+/-)-Cromakalim
100mg
$ 570.00

Tocris
Cromakalim ≥99%(HPLC)
10
$ 205.00

Sigma-Aldrich
Cromakalim
50mg
$ 788.00

Sigma-Aldrich
Cromakalim
10mg
$ 178.00

Medical Isotopes, Inc.
Cromakalim
10 mg
$ 190.00

Cayman Chemical
(±)-Cromakalim ≥99%
50mg
$ 396.00

Cayman Chemical
(±)-Cromakalim ≥99%
10mg
$ 99.00

Biosynth Carbosynth
(+/-)-Cromakalim
50 mg
$ 550.00

Biosynth Carbosynth
(+/-)-Cromakalim
100 mg
$ 1000.00

Biosynth Carbosynth
(+/-)-Cromakalim
25 mg
$ 300.00

Total 7 raw suppliers

Chemical Property of Cromakalim

Chemical Property:

Vapor Pressure:4.09E-10mmHg at 25°C
Melting Point:242-244oC
Boiling Point:482.3°Cat760mmHg
Flash Point:245.5°C
PSA：73.56000
Density:1.31g/cm³
LogP:1.69158
Storage Temp.:2-8°C
Solubility.:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:286.13174244
Heavy Atom Count:21
Complexity:481

Purity/Quality:

98%,99%, ^*data from raw suppliers

(+/-)-Cromakalim ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1(C(C(C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C
Isomeric SMILES:CC1([C@@H]([C@H](C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C
Description (±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 μM) and cardioprotective (IC50 = 0.03 μM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance.
Uses Cromakalim causes vasodilation by activation of potassim channels Cromakalim has been used:as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens. as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

Technology Process of Cromakalim

There total 6 articles about Cromakalim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%