Phenyl[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]methanone

Base Information

Chemical Name:Phenyl[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]methanone
CAS No.:90971-77-0
Molecular Formula:C20H29NOSi
Molecular Weight:327.542
Hs Code.:
DSSTox Substance ID:DTXSID801185572

Synonyms:DTXSID801185572;Phenyl[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]methanone;90971-77-0

Suppliers and Price of Phenyl[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenyl[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]methanone

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:327.201841083
Heavy Atom Count:23
Complexity:377

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)[Si](C(C)C)(C(C)C)N1C=CC(=C1)C(=O)C2=CC=CC=C2

Technology Process of Phenyl[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]methanone

There total 4 articles about Phenyl[1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 87630-35-1
N-triisopropylsilylpyrrole

: 98-88-4
benzoyl chloride

: 90971-77-0
3-benzoyl-1-(triisopropylsilyl)pyrrole

Guidance literature:: With aluminium trichloride; In dichloromethane; 1.) 0 deg C, 0.5 h, 2.) 25 deg C, 0.5 h;
DOI:10.1021/jo00313a019

Reference yield:

: 87630-35-1
N-triisopropylsilylpyrrole

: 90971-77-0
3-benzoyl-1-(triisopropylsilyl)pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NBS / tetrahydrofuran / -78 - 20 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h

With N-Bromosuccinimide; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jo00191a047

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 90971-77-0
3-benzoyl-1-(triisopropylsilyl)pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 1.25 h, 2.) 0 deg C, 0.75 h

2: 48 percent / AlCl₃ / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) 25 deg C, 0.5 h

With aluminium trichloride; sodium hydride; In dichloromethane;
DOI:10.1021/jo00313a019