(2S)-2-AMINO-5-HEXENOIC ACID

Base Information

• Chemical Name: (2S)-2-AMINO-5-HEXENOIC ACID
• CAS No.: 90989-12-1
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Mol file: 90989-12-1.mol

Synonyms:5-Hexenoic acid, 2-amino-, (S)-;(S)-2-Amino-5-hexenoic acid;(S)- 2-(3'-butenyl) glycine;(2S)-2-AMINO-5-HEXENOIC ACID;

Chemical Property of (2S)-2-AMINO-5-HEXENOIC ACID

Chemical Property:

• Melting Point: >270 °C
• Boiling Point: 242.0±28.0 °C(Predicted)
• PKA: 2.31±0.10(Predicted)
• PSA: 63.32000
• Density: 1.064±0.06 g/cm3(Predicted)
• LogP: 1.06480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Aminohex-5-enoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-AMINO-5-HEXENOIC ACID

There total 18 articles about (2S)-2-AMINO-5-HEXENOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ (2S)-2-amino-5-hexenoic acid (90989-12-1)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; water; at 60 ℃;

DOI:10.1016/j.tet.2004.06.087

Reference yield: 96.0%

1-bromo-4-butene (5162-44-7) → (2S)-2-amino-5-hexenoic acid (90989-12-1)

Guidance literature:

1-bromo-4-butene; Ni(II) complex of the Schiff base derived from glycine and (S)-2-[N'-(N-benzylprolyl)amino]benzophenone; With sodium hydroxide; In acetonitrile; at 20 ℃; for 3h;

With hydrogenchloride; water; In methanol; for 1h; Further stages.; Heating;

DOI:10.1039/a908140b

Reference yield: 77.0%

(S)-(-)-1-tert-butyl-2--5-hexenoate (226985-05-3) → (2S)-2-amino-5-hexenoic acid (90989-12-1)

Guidance literature:

(S)-(-)-1-tert-butyl-2--5-hexenoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With sodium hydroxide; In water; at 40 ℃; for 1h;

DOI:10.1002/anie.200903135

upstream raw materials:

(±)-2-acetamidohex-5-enoic acid

(R)-4-Methyl-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

1-bromo-4-butene

ethyl 2-acetamido-2-cyanoacetate

Downstream raw materials:

(S)-2-N-(tert-butoxycarbonyl)-2-amino-5-hexenoic acid

Fmoc-L-Asn(Trt)-L-Hag-OH

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hex-5-enoic acid

(2S)-1-(tert-butoxycarbonyl)-2-azepanecarboxylic acid