5162-44-7Relevant articles and documents
Formal Bromine Atom Transfer Radical Addition of Nonactivated Bromoalkanes Using Photoredox Gold Catalysis
Zidan, Montserrat,McCallum, Terry,Swann, Rowan,Barriault, Louis
supporting information, p. 8401 - 8406 (2020/11/03)
Organic transformations mediated by photoredox catalysis have been at the forefront of reaction discovery. Recently, it has been demonstrated that binuclear Au(I) bisphosphine complexes, such as [Au2(μ-dppm)2]X2, are capable of mediating electron transfer to nonactivated bromoalkanes for the generation of a variety of alkyl radicals. The transfer reactions of bromine, derived from nonactivated bromoalkanes, are largely unknown. Therefore, we propose that unique metal-based mechanistic pathways are at play, as this binuclear gold catalyst has been known to produce Au(III) Lewis acid intermediates. The scope and proposed mechanistic overview for the formal bromine atom transfer reaction of nonactivated bromoalkanes mediated by photoredox Au(I) catalysis is presented. The methodology presented afforded good yields and a broad scope which include examples using bromoalkanes and iodoarenes.
Asymmetric Synthesis of Carbocyclic Propellanes
Schneider, Lisa M.,Schmiedel, Volker M.,Pecchioli, Tommaso,Lentz, Dieter,Merten, Christian,Christmann, Mathias
supporting information, p. 2310 - 2313 (2017/05/12)
A modular synthesis of functionalized carbocyclic propellanes was developed. Formation of the first of two quaternary bridgehead centers has been achieved by desymmetrization of prostereogenic ketones by either Hajos-Parrish-Eder-Sauer-Wiechert-type processes or Werner’s catalytic asymmetric Wittig reaction. The obtained bicyclic enones were subjected to conjugate additions upon which the remaining ring was formed by olefin metathesis. All bridges are amenable to further derivatization, which renders those compounds useful as central units in fragment-based drug discovery or as ligand scaffolds.
Production of ethylcycloalkanes bromomethylbiphenyl
-
Paragraph 0039-0041, (2018/10/16)
PROBLEM TO BE SOLVED: To provide a production method by which bromomethyl cycloalkanes can be easily obtained in an industrial scale.SOLUTION: A method for producing bromomethyl cycloalkanes comprises brominating cycloalkyl methanols by use of hydrogen bromide, wherein the reaction is carried out in the presence of an ionic liquid.