4H-1,3-BENZODIOXIN,8-BROMO-2,2,6-TRIMETHYL-

Base Information

• Chemical Name: 4H-1,3-BENZODIOXIN,8-BROMO-2,2,6-TRIMETHYL-
• CAS No.: 91084-79-6
• Molecular Formula: C11H13BrO2
• Molecular Weight: 370.451
• Mol file: 91084-79-6.mol

Synonyms:4H-1,3-BENZODIOXIN,8-BROMO-2,2,6-TRIMETHYL-;

Chemical Property of 4H-1,3-BENZODIOXIN,8-BROMO-2,2,6-TRIMETHYL-

Chemical Property:

• PSA: 18.46000
• LogP: 3.40260

Purity/Quality:

99% ^*data from raw suppliers

4H-1,3-BENZODIOXIN,8-BROMO-2,2,6-TRIMETHYL- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1,3-BENZODIOXIN,8-BROMO-2,2,6-TRIMETHYL-

There total 4 articles about 4H-1,3-BENZODIOXIN,8-BROMO-2,2,6-TRIMETHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

1,3-bis(2-methoxy-3-nitro-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone (83604-29-9) → 1,3-bis(2-methoxy-3-amino-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone (91084-79-6)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 3h; Heating;

DOI:10.1021/ja00329a059

Reference yield:

2,6-dinitro-4-methylanisole (29455-11-6) → 1,3-bis(2-methoxy-3-amino-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone (91084-79-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / ammonium sulfide 22percent / methanol / 0.67 h / Heating

2: 90 percent / pyridine / tetrahydrofuran / 30 h / Heating

3: 70 percent / NaOH, benzyltriethylammonium bromide / benzene; H₂O / 96 h / 46 °C

4: 97.6 percent / iron powder, hydrochloric acid / ethanol; H₂O / 3 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; ammonium sulfide; benzyltriethylammonium bromide; iron; In tetrahydrofuran; methanol; ethanol; water; benzene;

DOI:10.1021/ja00329a059

Reference yield:

2-methoxy-3-nitro-5-methylaniline (83604-27-7) → 1,3-bis(2-methoxy-3-amino-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone (91084-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / pyridine / tetrahydrofuran / 30 h / Heating

2: 70 percent / NaOH, benzyltriethylammonium bromide / benzene; H₂O / 96 h / 46 °C

3: 97.6 percent / iron powder, hydrochloric acid / ethanol; H₂O / 3 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; benzyltriethylammonium bromide; iron; In tetrahydrofuran; ethanol; water; benzene;

DOI:10.1021/ja00329a059

upstream raw materials:

1,3-bis(2-methoxy-3-nitro-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone

2,6-dinitro-4-methylanisole

2-methoxy-3-nitro-5-methylaniline

1,3-bis(2-methoxy-3-nitro-5-methylphenyl)urea

Downstream raw materials:

33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene

1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

Refernces