Propanamide, N-[2-[4-[2-(4-bromophenyl)ethyl]-1-piperazinyl]-1-methylethyl]-N-(4-meth oxyphenyl)-

Base Information

• Chemical Name: Propanamide, N-[2-[4-[2-(4-bromophenyl)ethyl]-1-piperazinyl]-1-methylethyl]-N-(4-meth oxyphenyl)-
• CAS No.: 91098-77-0
• Molecular Formula: C₂₅H₃₄BrN₃O₂
• Molecular Weight: 488.468
• Mol file: 91098-77-0.mol

Synonyms:

Chemical Property of Propanamide, N-[2-[4-[2-(4-bromophenyl)ethyl]-1-piperazinyl]-1-methylethyl]-N-(4-meth oxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanamide, N-[2-[4-[2-(4-bromophenyl)ethyl]-1-piperazinyl]-1-methylethyl]-N-(4-meth oxyphenyl)-

There total 7 articles about Propanamide, N-[2-[4-[2-(4-bromophenyl)ethyl]-1-piperazinyl]-1-methylethyl]-N-(4-meth oxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-nitrophenyl)ethyl bromide (5339-26-4) → 1-<2-methyl-2-(N-propionyl-p-methoxyphenylamino)ethyl>-4-(p-bromophenethyl)piperazine (91098-77-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 72 percent / methanol; dioxane / 1.5 h / 60 °C

2: benzene / 1.5 h / 0 - 3 °C

3: 65.2 percent / K₂CO₃ / ethanol / 10 h / Heating

4: 76.9 percent / AlCl₃, NaBH₄ / tetrahydrofuran / 20 h / Heating

5: 64.6 percent / 3 h / 100 °C

6: 82.9 percent / H₂ / PtO₂ / ethanol / 4 h / Ambient temperature

7: 1.) NaNO₂; 2.) CuBr / 1.) HBr aq, 5 deg C, 2 h; 2.) HBr aq, r.t., overnight

With sodium tetrahydroborate; aluminium trichloride; hydrogen; potassium carbonate; copper(I) bromide; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; benzene;

DOI:10.1248/cpb.32.986

Reference yield:

2-Bromo-1-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propan-1-one (91098-70-3) → 1-<2-methyl-2-(N-propionyl-p-methoxyphenylamino)ethyl>-4-(p-bromophenethyl)piperazine (91098-77-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 65.2 percent / K₂CO₃ / ethanol / 10 h / Heating

2: 76.9 percent / AlCl₃, NaBH₄ / tetrahydrofuran / 20 h / Heating

3: 64.6 percent / 3 h / 100 °C

4: 82.9 percent / H₂ / PtO₂ / ethanol / 4 h / Ambient temperature

5: 1.) NaNO₂; 2.) CuBr / 1.) HBr aq, 5 deg C, 2 h; 2.) HBr aq, r.t., overnight

With sodium tetrahydroborate; aluminium trichloride; hydrogen; potassium carbonate; copper(I) bromide; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.32.986

Reference yield:

1-<2-(p-methoxyphenylamino)propionyl>-4-(p-nitrophenethyl)piperazine (91098-71-4) → 1-<2-methyl-2-(N-propionyl-p-methoxyphenylamino)ethyl>-4-(p-bromophenethyl)piperazine (91098-77-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 76.9 percent / AlCl₃, NaBH₄ / tetrahydrofuran / 20 h / Heating

2: 64.6 percent / 3 h / 100 °C

3: 82.9 percent / H₂ / PtO₂ / ethanol / 4 h / Ambient temperature

4: 1.) NaNO₂; 2.) CuBr / 1.) HBr aq, 5 deg C, 2 h; 2.) HBr aq, r.t., overnight

With sodium tetrahydroborate; aluminium trichloride; hydrogen; copper(I) bromide; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.32.986

upstream raw materials:

1-<2-methyl-2-(N-propionyl-p-methoxyphenylamino)ethyl>-4-(p-aminophenethyl)piperazine

(4-nitrophenyl)ethyl bromide

2-Bromo-1-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propan-1-one

1-<2-(p-methoxyphenylamino)propionyl>-4-(p-nitrophenethyl)piperazine