5339-26-4

Basic information

• Product Name: 4-Nitrophenethyl bromide
• Synonyms: P-NITROPHENETHYL BROMIDE;BENZENE, 1-(2-BROMOETHYL)-4-NITRO-;1-(2-BROMOETHYL)-4-NITROBENZENE;2-(4-NITROPHENYL)-1-BROMOETHANE;2-(4-NITROPHENYL)ETHYL BROMIDE;4-(NITROPHENYL)ETHYL BROMIDE;4-NITROPHENETHYL BROMIDE;1-Bromo-2-(4-nitrophenyl)ethane
• CAS NO: 5339-26-4
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.06
• EINECS: 226-271-7
• Mol File: 5339-26-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 67-69 °C(lit.)
• Boiling Point: 116°C/0.2mm
• Flash Point: 116°C/0.2mm
• Appearance: Yellow/Adhering Crystals or Crystalline Powder
• Density: 1.6270 (rough estimate)
• Vapor Pressure: 0.00115mmHg at 25°C
• Refractive Index: 1.6120 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform(Slightly), Dichloromethane (Slightly), Methanol (Slightly)
• Water Solubility: Soluble in water (partly) and methanol.
• BRN: 1909321
• CAS DataBase Reference: 4-Nitrophenethyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrophenethyl bromide(5339-26-4)
• EPA Substance Registry System: 4-Nitrophenethyl bromide(5339-26-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37-24/25
• WGK Germany: 3
• Hazardous Substances Data: 5339-26-4(Hazardous Substances Data)

Usage

Chemical Properties

yellowish adhering crystals or crystalline powder

Uses

4-nitrophenethyl bromide is used a s a GST T1-1 substrate for identifying many kinetic parameters (Km, Kcat) for hGST T1-1 variants.

General Description

4-nitrophenethyl bromide is an electrophile which accepts a lone pair of electrons from one of the nitrogen atoms in the polyazamacrocycle.

Biochem/physiol Actions

4-Nitrophenethyl bromide is used as a marker in for the θ-class of glutathione S-transferases (GSTs). It activates the human θ-class glutathione transferase T1-1 enzyme.

InChI:InChI=1/C8H8BrNO2/c9-6-5-7-1-3-8(4-2-7)10(11)12/h1-4H,5-6H2

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 100-13-0 4-nitrostyrene 
• 60-12-8 2-phenylethanol 
• 100-12-9 4-ethylnitrobenzene 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 104-03-0 4-nitrobenzeneacetic acid 
• 100-27-6 2-(4-nitrophenyl)ethanol 

Downstream Products

• 101603-37-6 ethyl 2-(N-acetamido)-2-(carboxyethyl)-4-(4-nitrophenyl)butanoate 
• 1879-55-6 (E)-1-nitro-4-(prop-1-en-1-yl)benzene 
• 266678-25-5 4-[4-(2-piperidin-1-yl-ethyl)-phenylcarbamoyl]-butyric acid 2-{ethyl-[4-(4-nitro-phenylazo)-phenyl]-amino}-ethyl ester 
• 134529-13-8 1'-(2-(4-nitrophenyl)ethyl)-2,3'-bipyridinium iodide 
• 134529-14-9 1-methyl-1'-(2-(4-nitrophenyl)ethyl)-2,3'-bipyridinium diiodide 
• 139879-17-7 DL-4-(4-aminophenyl)-2-aminobutanoic acid 
• 233772-16-2 methyl(4-nitrophenethyl)sulfane 
• 796847-63-7 1-{1-[2-(4-nitrophenyl)ethyl]piperidin-4-yl}methanamine 
• 53563-09-0 3-(4-nitrophenyl)propanenitrile 
• 52059-41-3 N-Methyl-β-(p-aminophenyl)-β-phenyl-diethylamin 
• 101350-76-9 2-[2-(4-aminophenyl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 51-67-2 tyrosamine 
• 13472-00-9 p-Aminophenethylamine 
• 168897-21-0 4-(2-piperidin-1-yl-ethyl)-phenylamine 

Relevant articles and documents

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins

To improve access to a key synthetic intermediate we targeted a direct hydrobromination-Negishi route. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed. Re-examination of early reports revealed that selective Markovnikov addition, often simply termed "normal" addition, is not always observed with HBr unless air is excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol.

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease

A series of ebselen derivatives were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and glutathione peroxidase (GPx) mimics. Most of the compounds were found to be potent against AChEs and BuChE, compounds 5e and 5i, proved to be the most potent against AChE with IC50 values of 0.76 and 0.46 μM, respectively. Among these hybrids, most of the compounds were found to be good GPx mimics compare with ebselen. The selected compounds 5e and 5i were also used to determine the catalytic parameters and in vitro hydrogen peroxide scavenging activity. The results indicate that compounds 5e and 5i may be excellent multifunctional agents for the treatment of AD.

Catalytic processes of oxidation by hydrogen peroxide in the presence of Br2 or HBr. Mechanism and synthetic applications

The mechanism and the synthetic applications for the oxidation of alcohols, ethers, and aldehydes by H2O2 catalyzed by Bf2 or Br- in a liquid two-phase system (aqueous and organic) are reported. Aliphatic and benzylic primary alcohols and ethers show an opposite behavior, which has been rationalized on the ground of the different electronic configurations of the intermediate alkyl (π-type) and acyl (σ-type) radicals and their influence on enthalpic and polar effects. A two-phase system is particularly useful also for an efficient benzylic bromination by Br2 or Br-; the substitution of the benzyl bromide by OH, OR, and OCOR regenerates Br-, which can be recycled. The evaluation of the relative reactivities of the involved substrates and intermediates has allowed to develop a variety of simple, facile, convenient, and selective syntheses of alcohols, aldehydes, ketones, esters, and benzyl bromides, which fulfill the conditions for practical applications.