Epinephrine Hydrochloride

Base Information

• Chemical Name: Epinephrine Hydrochloride
• CAS No.: 55-31-2
• Deprecated CAS: 39836-34-5,66240-90-2,66240-90-2
• Molecular Formula: C9H14ClNO3
• Molecular Weight: 219.668
• European Community (EC) Number: 200-230-3
• UN Number: 2811
• UNII: WBB047OO38
• DSSTox Substance ID: DTXSID1020568
• Wikipedia: Adrenaline
• Wikidata: Q27107122
• NCI Thesaurus Code: C74941
• Metabolomics Workbench ID: 47536
• ChEMBL ID: CHEMBL3183376
• Mol file: 55-31-2.mol

Synonyms:4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol;Acetate, Epinephrine;Adrenaline;Adrenaline Acid Tartrate;Adrenaline Bitartrate;Adrenaline Hydrochloride;Epifrin;Epinephrine;Epinephrine Acetate;Epinephrine Bitartrate;Epinephrine Hydrochloride;Epinephrine Hydrogen Tartrate;Epitrate;Lyophrin;Medihaler-Epi

Chemical Property of Epinephrine Hydrochloride

Chemical Property:

• Appearance/Colour: crystals
• Melting Point: 157 °C
• Boiling Point: 413.1 °C at 760 mmHg
• Flash Point: 207.9 °C
• PSA: 72.72000
• LogP: 1.54350
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 219.0662210
• Heavy Atom Count: 14
• Complexity: 154
• Transport DOT Label: Poison

Purity/Quality:

≥99% ^*data from raw suppliers

EpinephrineHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: UVCB,Other Uses -> Food Additives
• Canonical SMILES: CNCC(C1=CC(=C(C=C1)O)O)O.Cl
• Isomeric SMILES: CNC[C@@H](C1=CC(=C(C=C1)O)O)O.Cl
• Recent ClinicalTrials: Management of Shock in Children With SAM or Severe Underweight and Diarrhea
• Recent EU Clinical Trials: Ultrasound-guided Genicular Nerve Block an Analgesic Alternative to LIA for
• Recent NIPH Clinical Trials: Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria

Technology Process of Epinephrine Hydrochloride

There total 1 articles about Epinephrine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C44H36N4O12P2(2-)*C9H13NO3*H(1+) → epinephrine hydrochloride (55-31-2,66240-90-2) + C44H36N4O12P2(2-)

Guidance literature:

In d⁽⁴⁾-methanol; water-d2; Equilibrium constant;

DOI:10.1002/1521-3773(20010903)40:17<3148::AID-ANIE3148>3.0.CO;2-S

Reference yield: 99.0%

potassium acesulfame (55589-62-3) + epinephrine hydrochloride (55-31-2,66240-90-2) → epinephrine acesulfamate

Guidance literature:

In acetonitrile; at 50 ℃; for 4h; Sonication;

Reference yield: 96.0%

saccharin sodium salt (128-44-9) + epinephrine hydrochloride (55-31-2,66240-90-2) → epinephrine saccharinate

Guidance literature:

In acetonitrile; at 50 ℃; for 4h; Sonication;

Downstream raw materials:

adrenochrome

Refernces