7-benzyl-2-methyl-2,7-diazaspiro[4.4]nonane-1,3,8-trione

Base Information

• Chemical Name: 7-benzyl-2-methyl-2,7-diazaspiro[4.4]nonane-1,3,8-trione
• CAS No.: 91189-25-2
• Molecular Formula: C15H16N2O3
• Molecular Weight: 272.304
• Mol file: 91189-25-2.mol

Synonyms:7-Benzyl-2,6-dichlor-9H-purin;2,6-Dichlor-7-benzyl-7H-purin;N-7-benzyl-2,6-dichloro-7H-purine;2,6-dichloro-7-benzylpurine;Purine,7-benzyl-2,6-dichloro;7-benzyl-2,6-dichloro-7H-purine;

Chemical Property of 7-benzyl-2-methyl-2,7-diazaspiro[4.4]nonane-1,3,8-trione

Chemical Property:

• Vapor Pressure: 2.83E-11mmHg at 25°C
• Boiling Point: 528.9oC at 760 mmHg
• Flash Point: 262.2oC
• PSA: 57.69000
• Density: 1.33g/cm3
• LogP: 0.66980

Purity/Quality:

2,7-DIAZASPIRO[4.4]NONANE-1,3,8-TRIONE, 2-METHYL-7-(PHENYLMETHYL)- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyl-2-methyl-2,7-diazaspiro[4.4]nonane-1,3,8-trione

There total 3 articles about 7-benzyl-2-methyl-2,7-diazaspiro[4.4]nonane-1,3,8-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2,7-diazaspiro<4.4>nonane-1,3,8-trione (91189-24-1) + benzyl chloride (100-44-7) → 2-Methyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]-nonane-1,3,8-trione (91189-25-2)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 1 h, 2.) RT, overnight;

DOI:10.1021/jm00170a035

Reference yield:

triethyl 2-cyano-1,2,3-propanetricarboxylate (20822-61-1) → 2-Methyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]-nonane-1,3,8-trione (91189-25-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / H₂, triethylamine / Raney cobalt / dimethylformamide / 23 h / 124116 - 279260 Torr

2: 76.2 percent / H₂O / 1.) RT, overnight, 2.) from RT to 220 deg C, 1 h

3: 1.) NaH / 1.) DMF, 1 h, 2.) RT, overnight

With hydrogen; sodium hydride; triethylamine; cobalt; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm00170a035

Reference yield:

ethyl 3-(ethoxycarbonyl)-5-oxo-3-pyrrolidineacetate (91189-23-0) → 2-Methyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]-nonane-1,3,8-trione (91189-25-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.2 percent / H₂O / 1.) RT, overnight, 2.) from RT to 220 deg C, 1 h

2: 1.) NaH / 1.) DMF, 1 h, 2.) RT, overnight

With sodium hydride; In water;

DOI:10.1021/jm00170a035

upstream raw materials:

2-methyl-2,7-diazaspiro<4.4>nonane-1,3,8-trione

benzyl chloride

triethyl 2-cyano-1,2,3-propanetricarboxylate

ethyl 3-(ethoxycarbonyl)-5-oxo-3-pyrrolidineacetate

Downstream raw materials:

2-methyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane dihydrochloride

2-methyl-7-(phenylmethyl)-2,7-diazaspiro<4.4>nonane

Refernces

• 1、 -. "4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents". . . Retrieved 2008/06/13.
• 2、 -. "Antibacterial agents". . . Retrieved 2008/06/13.