2-Amino-5-nitrobenzamide

Base Information

• Chemical Name: 2-Amino-5-nitrobenzamide
• CAS No.: 16313-65-8
• Molecular Formula: C7H7 N3 O3
• Molecular Weight: 181.151
• Hs Code.: 2924299090
• NSC Number: 142033
• DSSTox Substance ID: DTXSID00167521
• Nikkaji Number: J29.496I
• Wikidata: Q83036912
• Mol file: 16313-65-8.mol

Synonyms:2-Amino-5-nitrobenzamide;16313-65-8;5-Nitroanthranilamide;Benzamide, 2-amino-5-nitro-;2-Amino-5-nitro benzamide;MFCD00090235;NSC142033;2-amino-5-nitro-benzamide;Oprea1_177136;SCHEMBL346217;SCHEMBL22890327;DTXSID00167521;TQP0789;STK365713;AKOS005442711;CS-W008532;NSC 142033;NSC-142033;AS-19949;LS-25592;FT-0672747;EN300-128525;A882644;A908145;Z959893168

Chemical Property of 2-Amino-5-nitrobenzamide

Chemical Property:

• Vapor Pressure: 2.48E-05mmHg at 25°C
• Melting Point: 236.4-237.0 °C
• Boiling Point: 358.8°Cat760mmHg
• PKA: 14.63±0.50(Predicted)
• Flash Point: 170.8°C
• PSA: 114.93000
• Density: 1.481g/cm³
• LogP: 2.08060
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 181.04874109
• Heavy Atom Count: 13
• Complexity: 226

Purity/Quality:

97% ^*data from raw suppliers

5-Nitroanthranilamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])C(=O)N)N
• Uses: Intermediate in the preparation of nitro substituted quinazolones.

Technology Process of 2-Amino-5-nitrobenzamide

There total 10 articles about 2-Amino-5-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-nitroanthranilonitrile (17420-30-3) → 2-amino-5-nitrobenzamide (16313-65-8)

Guidance literature:

With sulfuric acid; at 130 ℃; for 0.333333h;

DOI:10.1002/ardp.19943270905

Reference yield: 88.0%

2-amino-5-nitro-benzoic acid (616-79-5) → 2-amino-5-nitrobenzamide (16313-65-8)

Guidance literature:

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/S0968-0896(02)00440-6

Reference yield: 85.0%

6-nitroisatoic anhydride (4693-02-1) → 2-amino-5-nitrobenzamide (16313-65-8)

Guidance literature:

With ammonium carbonate; In 1,4-dioxane; at 60 ℃; for 12h;

DOI:10.1002/anie.201908959

upstream raw materials:

2-bromo-5-nitrobenzamide

5-Bromo-1H-indole-2,3-dione

5-nitroanthranilonitrile

2-amino-5-nitro-benzoic acid

Downstream raw materials:

ethyl {[2-(aminocarbonyl)-4-nitrophenyl]amino}(oxo)acetate

6-Nitro-2,3-dihydro-1H-chinazolin-2-spiro-1'-cyclopentan-4-on

2-methyl-6-nitroquinazolin-4(3H)-one

5-nitro-2-[N-(pyridin-3-ylcarbonyl)amino]benzamide