diethyl 3-(cyanomethylene)pentanedioate

Base Information

• Chemical Name: diethyl 3-(cyanomethylene)pentanedioate
• CAS No.: 91248-21-4
• Molecular Formula: C11H15NO4
• Molecular Weight: 225.24
• Mol file: 91248-21-4.mol

Synonyms:

Chemical Property of diethyl 3-(cyanomethylene)pentanedioate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Diethyl3-(cyanomethylene)pentanedioate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 3-(cyanomethylene)pentanedioate

There total 2 articles about diethyl 3-(cyanomethylene)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyanoacetic acid (372-09-8) + diethyl 1,3-acetonedicarboxylate (105-50-0) → diethyl β-cyanomethylideneglutarate (91248-21-4)

Guidance literature:

With ammonium acetate; acetic acid; In benzene; for 24h; Heating;

Reference yield:

→ diethyl β-cyanomethylideneglutarate (91248-21-4)

Guidance literature:

Cyanessigsaeure, 3-Oxo-glutarsaeure-diaethylester, β-Alanin, Eg., wfr., Siedetemp. (Badtemp. 140-150grad);

Reference yield:

diethyl β-cyanomethylideneglutarate (91248-21-4) → N-β-(3,4-Dimethoxyphenethyl)-3-(3,4-dimethoxyphenethylcarbamoylmethyl)glutarimide (112521-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / hydrogen / 10percent Pd/C / ethanol / 5 h

2: 60 percent / hydrochloric acid / 1) H₂O, reflux, 15 h, 2) at 235 deg C, 5 h

3: 25 percent / xylene / 18 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; xylene;

upstream raw materials:

cyanoacetic acid

diethyl 1,3-acetonedicarboxylate

Downstream raw materials:

(2-oxo-[4]piperidyl)-acetic acid ethyl ester

3,3'-(3-aza-pentanediyl)-di-glutaric acid tetraethyl ester

(2,6-dioxopiperidin-4-yl)acetic acid

N-β-(3,4-Dimethoxyphenethyl)-3-(3,4-dimethoxyphenethylcarbamoylmethyl)glutarimide

Refernces

• 1、 Gupta, K. A.,Saxena, Anil K.,Jain, Padam C.,Anand, Nitya. "Synthesis and Biological Activity of 3-(6,7-Dimethoxy-1,2,3,4-tetrahydro-1-isoquinolylmethyl)glutarimide". . p. 341 - 343. Retrieved 2007/10/02.