5,5-dimethylcyclophosphamide

Base Information

• Chemical Name: 5,5-dimethylcyclophosphamide
• CAS No.: 22089-27-6
• Molecular Formula: C₉H₁₉Cl₂N₂O₂P
• Molecular Weight: 289.142
• Mol file: 22089-27-6.mol

Synonyms:2H-1,3,2-Oxazaphosphorine,2-[bis(2-chloroethyl)amino]tetrahydro-5,5-dimethyl-, 2-oxide (6CI,8CI);5,5-Dimethylcyclophosphamide; Asta B 707; Asta Bx 707

Chemical Property of 5,5-dimethylcyclophosphamide

Chemical Property:

• Vapor Pressure: 5.88E-05mmHg at 25°C
• Boiling Point: 346.1°Cat760mmHg
• Flash Point: 163.1°C
• PSA: 51.38000
• Density: 1.26g/cm³
• LogP: 2.84890

Purity/Quality:

5,5-DIMETHYLCYCLOPHOSPHAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,5-dimethylcyclophosphamide

There total 1 articles about 5,5-dimethylcyclophosphamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N,N-di(2-chloroethyl)amidophosphoric acid dichloride (127-88-8) + 3-amino-2,2-dimethylpropan-1-ol (26734-09-8) → 2-(bis-(2-chloroethyl)amino)-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane (22089-27-6)

Guidance literature:

With triethylamine; In ethyl acetate; for 144h; Ambient temperature;

DOI:10.1021/ja00293a044

upstream raw materials:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride

3-amino-2,2-dimethylpropan-1-ol

Refernces