26734-09-8

Basic information

• Product Name: 3-AMINO-2,2-DIMETHYL-1-PROPANOL
• Synonyms: 3-Hydroxy-2,2-dimethylpropylamine;2,2-DiMethyl-3-aMinopropanol;3-Amino-2,2-dimethylpropanol(Oxalate form);3-AMINO-2,2-DIMETHYL-1-PROPANOL;3-AMINO-2,2-DIMETHYLPROPANOL;NEOPENTANOLAMINE;3-amino-2,2-dimethyl-1-propano;3-amino-2,2-dimethylpropan-1-ol
• CAS NO: 26734-09-8
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.16
• EINECS: 247-948-3
• Product Categories: Miscellaneous Reagents;Aliphatics;Amines
• Mol File: 26734-09-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 70°C
• Boiling Point: 80°C@20mmHg
• Flash Point: 62℃
• Appearance: Colourless solid
• Density: 0.918
• Vapor Pressure: 0.285mmHg at 25°C
• Refractive Index: 1.451
• Storage Temp.: -20°C Freezer
• Solubility: Soluble in Dichloromethane, Chloroforn, Ether and Methanol
• PKA: 15.10±0.10(Predicted)
• Water Solubility: very faint turbidity
• Sensitive: Hygroscopic
• BRN: 1731900
• CAS DataBase Reference: 3-AMINO-2,2-DIMETHYL-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2,2-DIMETHYL-1-PROPANOL(26734-09-8)
• EPA Substance Registry System: 3-AMINO-2,2-DIMETHYL-1-PROPANOL(26734-09-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38-41-37/38
• Safety Statements: 26-36-39
• RIDADR: 3263
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 26734-09-8(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Solid

Uses

Reatant in the synthesis of cyclic carbamates, cryptophycin analogues. Neopentanolamine with ammonia and hydrogen yeilds neopentyldiamine.

InChI:InChI=1/C5H13NO/c1-5(2,3-6)4-7/h7H,3-4,6H2,1-2H3

Upstream product

• 597-31-9 2,2-dimethyl-3-hydroxypropionaldehyde 
• 59676-94-7 bis-(3-hydroxy-2,2-dimethyl-propylidene)-hydrazine 
• 1572-98-1 2-cyano-2-methyl-propionic acid ethyl ester 
• 51916-35-9 3-azido-2,2-dimethyl-1-propanol 
• 19295-57-9 3-hydroxy-2,2-dimethylpropionitrile 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 67-56-1 methanol 
• 7664-41-7 ammonia 
• 40894-00-6 3-bromo-2,2-dimethyl-propan-1-ol 

Downstream Products

• 130001-05-7 (E)-2-<(4-chlorpbenzoyl)methylene>-5,5-dimethyl-tetrahydro-2H-1,3-oxazine 
• 130001-04-6 (E)-2-(benzoylmethylene)-5,5-dimethyl-tetrahydro-2H-1,3-oxazine 
• 136145-00-1 2-anilino-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 85289-25-4 5,5-Dimethyl-2-phenoxy-[1,3,2]oxazaphosphinane 2-sulfide 
• 64957-84-2 4,5-dihydro-2-(2',4'-dimethoxyphenyl)-4,4-dimethyloxazole 
• 136144-98-4 2-(p-methoxyanilino)-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 136145-01-2 2-(p-nitroanilino)-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 136144-97-3 2-(4-dimethylaminoanilino)-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 908144-23-0 3-(2,4-dimethoxybenzylamino)-2,2-dimethylpropan-1-ol 
• 222037-06-1 4-amino-N-(3-hydroxy-2,2-dimethyl-propyl)benzenesulfonamide 
• 222035-36-1 GW₃₀₁₇₈₄X 

Relevant articles and documents

HIV INTEGRASE INHIBITORS

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

A new synthesis of bicyclic N,O- and N,S-enaminals by the anionic cyclization of alk-4-ynals with amino alcohols and amino thiols

A reaction of alk-4-ynals with aliphatic amino alcohols or 2-aminoethanethiol in the system DMSO - KOH gives bicyclic N,O- and N,S-enaminals: 6-methylidenehexahydro-2H-pyrrolo[2,1-b][1,3]oxazines, 5-methylidenehexahydropyrrolo[2,1-b]oxazoles, or 5-methyl-

Continuous amination of propanediols in supercritical ammonia

Enhancements in selectivity by a factor of 4 to 18 were observed in the near critical regions of ammonia during the Co- and Ni-catalyzed synthesis of 1,3-diamino-propanes. These results are attributed to the higher concentration of ammonia at the surface of the catalyst, which favors the amination and suppresses degredation reactions.