3-amino-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo(2.2.1)heptane

Base Information

• Chemical Name: 3-amino-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo(2.2.1)heptane
• CAS No.: 118891-94-4
• Molecular Formula: C13H17 N O3
• Molecular Weight: 235.283
• Mol file: 118891-94-4.mol

Synonyms:3-amino-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo(2.2.1)heptane

Chemical Property of 3-amino-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo(2.2.1)heptane

Chemical Property:

• Vapor Pressure: 1.95E-09mmHg at 25°C
• Boiling Point: 464.7°C at 760 mmHg
• Flash Point: 234.9°C
• PSA: 86.71000
• Density: 1.39g/cm³
• LogP: 1.74290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-amino-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo(2.2.1)heptane

There total 4 articles about 3-amino-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo(2.2.1)heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

endo-3-amino-exo-2-<3,4-bis(benzyloxy)phenyl>-2-hydroxybicyclo<2.2.1>heptane (118920-11-9) → endo-3-amino-exo-2-(3,4-dihydroxyphenyl)-2-hydroxy-bicyclo<2.2.1>heptane (118891-94-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; at 50 ℃; under 760 Torr; Yield given;

DOI:10.1021/jm00124a020

Reference yield:

3-(hydroxyimino)-2-oxobicyclo<2.2.1>heptane (28043-14-3) → endo-3-amino-exo-2-(3,4-dihydroxyphenyl)-2-hydroxy-bicyclo<2.2.1>heptane (118891-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 7 h / Heating

2: LAH / diethyl ether / 6 h / Heating

3: H₂ / 10percent Pd-C / CH₂Cl₂; ethanol / 50 °C / 760 Torr

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;

DOI:10.1021/jm00124a020

Reference yield:

<3,4-bis(benzyloxy)phenyl>magnesium bromide (16047-57-7) → endo-3-amino-exo-2-(3,4-dihydroxyphenyl)-2-hydroxy-bicyclo<2.2.1>heptane (118891-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 7 h / Heating

2: LAH / diethyl ether / 6 h / Heating

3: H₂ / 10percent Pd-C / CH₂Cl₂; ethanol / 50 °C / 760 Torr

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;

DOI:10.1021/jm00124a020

upstream raw materials:

endo-3-amino-exo-2-<3,4-bis(benzyloxy)phenyl>-2-hydroxybicyclo<2.2.1>heptane

3-(hydroxyimino)-2-oxobicyclo<2.2.1>heptane

<3,4-bis(benzyloxy)phenyl>magnesium bromide

exo-2-<3,4-bis(benzyloxy)phenyl>-2-hydroxy-3-(hydroxyimino)bicyclo<2.2.1>heptane