6-Ethyl-4-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 6-Ethyl-4-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
• CAS No.: 91487-37-5
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Hs Code.: 2933399090
• Mol file: 91487-37-5.mol

Synonyms:6-Ethyl-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;3-CYANO-4-METHYL-6-ETHYL-2-PYRIDONE;6-ethyl-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile;

Chemical Property of 6-Ethyl-4-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property:

• Melting Point: 240-241 °C
• Boiling Point: 343.8±35.0 °C(Predicted)
• PKA: 9.06±0.10(Predicted)
• PSA: 56.65000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 1.11738

Purity/Quality:

95+% ^*data from raw suppliers

6-Ethyl-4-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Ethyl-4-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

There total 9 articles about 6-Ethyl-4-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-amino-4-hexen-3-one (33663-57-9) + malononitrile (109-77-3) → 6-ethyl-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrileile (91487-37-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield: 32.0%

E-4-hexen-3-one (50396-96-8,130981-55-4,2497-21-4,50396-87-7) + cyanoacetic acid amide (107-91-5) → 6-ethyl-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrileile (91487-37-5)

Guidance literature:

cyanoacetic acid amide; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.25h; Inert atmosphere;

E-4-hexen-3-one; In dimethyl sulfoxide; at 20 ℃; for 3h; Inert atmosphere;

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b00855

Reference yield: 24.0%

ethyl acetate (141-78-6) + butanone (78-93-3) + cyanoacetic acid amide (107-91-5) → 6-ethyl-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrileile (91487-37-5)

Guidance literature:

ethyl acetate; butanone; With sodium; In diethyl ether; at 20 ℃; Cooling with ice;

cyanoacetic acid amide; In diethyl ether; at 20 ℃; for 0.1h;

With piperidine; water; acetic acid; In diethyl ether; for 2h; Reflux;

DOI:10.3390/molecules23071784

upstream raw materials:

hexane-2,4-dione

cyanoacetic acid amide

5-amino-4-hexen-3-one

malononitrile