5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]- 6,7-dihydro-2-methyl-5-oxo-, phenylmethyl ester

Base Information

• Chemical Name: 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]- 6,7-dihydro-2-methyl-5-oxo-, phenylmethyl ester
• CAS No.: 915297-18-6
• Molecular Formula: C32H33Cl2N3O5
• Molecular Weight: 610.537

Synonyms:

Chemical Property of 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]- 6,7-dihydro-2-methyl-5-oxo-, phenylmethyl ester

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Technology Process of 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]- 6,7-dihydro-2-methyl-5-oxo-, phenylmethyl ester

There total 1 articles about 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]- 6,7-dihydro-2-methyl-5-oxo-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate (915296-81-0,915731-56-5,915731-57-6) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → Benzyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915297-18-6)

Guidance literature:

With triethylamine; In acetonitrile; at 110 ℃; for 3h;

Reference yield:

Benzyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915297-18-6) → 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid (915297-19-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2h;

upstream raw materials:

3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate

1-(tert-butoxycarbonyl)-4-aminopiperidine

Downstream raw materials:

6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

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