2(1H)-Quinolinone, 3,4-dihydro-5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-8-hydroxy-, monohydrochloride

Base Information

Chemical Name:2(1H)-Quinolinone, 3,4-dihydro-5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-8-hydroxy-, monohydrochloride
CAS No.:65008-41-5
Molecular Formula:C22H28 N2 O6 . Cl H
Molecular Weight:452.9285
Hs Code.:
DSSTox Substance ID:DTXSID30983554

Synonyms:8-Hydroxy-5-(2-hydroxy-3-(beta-3,4-dimethoxyphenethylamino))propoxy-3,4-dihydrocarbostyril HCl;2(1H)-Quinolinone, 3,4-dihydro-5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-8-hydroxy-, monohydrochloride;65008-41-5;C22H28N2O6.ClH;SCHEMBL11381104;DTXSID30983554;MOZYNPVNFGHRGA-UHFFFAOYSA-N;C22-H28-N2-O6.Cl-H;LS-142703;5-(3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-2-hydroxypropoxy)-3,4-dihydroquinoline-2,8-diol--hydrogen chloride (1/1);5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Suppliers and Price of 2(1H)-Quinolinone, 3,4-dihydro-5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-8-hydroxy-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 2(1H)-Quinolinone, 3,4-dihydro-5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-8-hydroxy-, monohydrochloride

Chemical Property:

Vapor Pressure:1.71E-20mmHg at 25°C
Boiling Point:698.7°Cat760mmHg
Flash Point:376.4°C
Density:g/cm³
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:452.1714143
Heavy Atom Count:31
Complexity:536

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCNCC(COC2=C3CCC(=O)NC3=C(C=C2)O)O)OC.Cl

Technology Process of 2(1H)-Quinolinone, 3,4-dihydro-5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-8-hydroxy-, monohydrochloride

There total 4 articles about 2(1H)-Quinolinone, 3,4-dihydro-5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-8-hydroxy-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59430-56-7
5,8-Dihydroxy-3,4-dihydro-2(1H)-quinolinone

: 65008-41-5
5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / K₂CO₃ / acetone; H₂O / 4 h / Heating

2: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

3: 43.6 percent / methanol / 20 h / Ambient temperature

4: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol; acetone;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59826-16-3
8-(Benzyloxy)-5-hydroxy-3,4-dihydro-2(1H)-quinolinone

: 65008-41-5
5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

2: 43.6 percent / methanol / 20 h / Ambient temperature

3: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol;
DOI:10.1248/cpb.29.2166

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 65008-41-5
5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 43.6 percent / methanol / 20 h / Ambient temperature

2: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In methanol; water;
DOI:10.1248/cpb.29.2166