p-Chloroamphetamine hydrochloride

Base Information

• Chemical Name: p-Chloroamphetamine hydrochloride
• CAS No.: 3706-38-5
• Molecular Formula: C9H12 Cl N . Cl H
• Molecular Weight: 206.115
• Hs Code.: 2921499090
• European Community (EC) Number: 624-453-4
• UNII: LFH284HAG2
• ChEMBL ID: CHEMBL544709
• Mol file: 3706-38-5.mol

Synonyms:p-Chloroamphetamine hydrochloride;3706-38-5;DL-p-Chloroamphetamine hydrochloride;p-Chloramphetamine hydrochloride;4-Chloroamphetamine hydrochloride;1-(4-chlorophenyl)propan-2-amine hydrochloride;25356-95-0;Ro 4-6614/001;4-Chloroamphetamine HCl;1-(4-chlorophenyl)propan-2-amine;hydrochloride;(+-)-p-Chloroamphetamine hydrochloride;LFH284HAG2;p-chloro-alpha-methyl-phenethylamin hydrochloride;dl-1-(4-Chlorophenyl)-2-aminopropane hydrochloride;(+-)-p-Chloro-alpha-methylphenethylamine hydrochloride;Phenethylamine, p-chloro-alpha-methyl-, hydrochloride, (+-)-;C9-H12-Cl-N.Cl-H;Phenethylamine, p-chloro-alpha-methyl-, hydrochloride;Benzeneethanamine, 4-chloro-alpha-methyl-, hydrochloride;C9H12ClN.ClH;UNII-LFH284HAG2;CHEMBL544709;SCHEMBL1168686;4-Chloroamphetamine (hydrochloride);AKOS024307492;DL-4-CHLORAMPHETAMINE HYDROCHLORIDE;LS-103239;LS-103242;(+/-)-P-CHLORAMPHETAMINE HYDROCHLORIDE;(+/-)-4-CHLOROAMPHETAMINE HYDROCHLORIDE;DL-p-Chloroamphetamine hydrochloride, >=94% (HPLC);Phenethylamine, p-chloro-.alpha.-methyl-, hydrochloride;Benzeneethanamine, 4-chloro-.alpha.-methyl-, hydrochloride;Benzeneethanamine, 4-chloro-alpha-methyl-, hydrochloride (9CI);Benzeneethanamine, 4-chloro-.alpha.-methyl-, hydrochloride, (.+.)-;BENZENEETHANAMINE, 4-CHLORO-.ALPHA.-METHYL-, HYDROCHLORIDE (1:1);BENZENEETHANAMINE, 4-CHLORO-.ALPHA.-METHYL-, HYDROCHLORIDE, (+/-)-

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Chemical Property of p-Chloroamphetamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0307mmHg at 25°C
• Melting Point: 168-170 °C(lit.)
• Boiling Point: 244.2°Cat760mmHg
• Flash Point: 117°C
• PSA: 26.02000
• Density: g/cm³
• LogP: 3.73200
• Storage Temp.: −20°C
• Solubility.: DMSO: >20mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 205.0425048
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)Cl)N.Cl
• Uses: p-Chloroamphetamine Hydrochloride (PCA), is an Amphetamine (A634240) derivative and monoamine releaser similar to MDMA, but with higher neurotoxicity, thought to be due to the unrestrained release of both serotonin and dopamine by a metabolite.

Technology Process of p-Chloroamphetamine hydrochloride

There total 1 articles about p-Chloroamphetamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ p-chloroamphetamine hydrochloride (3706-38-5,25356-95-0)

Guidance literature:

Reference yield: 98.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + p-chloroamphetamine hydrochloride (3706-38-5,25356-95-0) → (+/-)-4-chloroamphetamine-(R)-MTPA amide

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ac970561h

Reference yield: 93.0%

p-chloroamphetamine hydrochloride (3706-38-5,25356-95-0) + 2,6-Dichlorobenzoyl chloride (4659-45-4) → 2,6-dichloro-N-[2-(4-chlorophenyl)-1-methylethyl]benzamide

Guidance literature:

p-chloroamphetamine hydrochloride; 2,6-Dichlorobenzoyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In dichloromethane; water;

Downstream raw materials:

(S)-α-(p-chlorobenzyl)ethylamine hydrochloride

(R)-2-amino-1-(p-chlorophenyl)propane hydrochloride