4659-45-4

Basic information

• Product Name: 2,6-Dichlorobenzoyl chloride
• Synonyms: Benzoyl chloride, 2,6-dichloro-;DICHLOROBENZOYLCHLORIDE(2,6-);2,6-DICHLOROBENZOYL CHLORIDE;2,6-DICHLORBENZOYL CHLORIDE;Benzoyl chloride, 2,6-dichloro- (6CI,7CI,8CI,9CI);2,6-Dichlorobenzoyl;2,6-Dichlorbenzoylchlorid;2,6-DICHLOROBENZOYL CHLORIDE 98+%
• CAS NO: 4659-45-4
• Molecular Formula: C7H3Cl3O
• Molecular Weight: 209.46
• EINECS: 225-102-4
• Product Categories: ACIDHALIDE;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 4659-45-4.mol
• Article Data: 24

Chemical Properties

• Melting Point: 15-17 °C
• Boiling Point: 142-143 °C21 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow or light pink/Liquid
• Density: 1.462 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: n20/D 1.560(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water.
• Sensitive: Moisture Sensitive
• BRN: 639531
• CAS DataBase Reference: 2,6-Dichlorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichlorobenzoyl chloride(4659-45-4)
• EPA Substance Registry System: 2,6-Dichlorobenzoyl chloride(4659-45-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 1
• F: 10-19-21
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 4659-45-4(Hazardous Substances Data)

Usage

Chemical Properties

Clear slightly yellow liquid

Uses

Different sources of media describe the Uses of 4659-45-4 differently. You can refer to the following data:
1. 2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.
2. 2,6-Dichlorobenzoyl chloride was used:in substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteasesin the synthesis of 1-acyliridolesin enantiocontrolled total synthesis of (-)-aspicilin

General Description

2,6-Dichlorobenzoyl chloride participates in esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

Purification Methods

Reflux the acid chloride for 2hours with excess of acetyl chloride (3 volumes), distil off AcCl followed by the benzoyl chloride. Store it away from moisture. It is an IRRITANT.[Beilstein 9 III 1377.]

InChI:InChI=1/C7H3Cl3O/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H

Upstream product

• 50-30-6 2,6-dichlorobenzoic acid 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 39887-33-7 N-(n-Propyl)-2,6-dichlorbenzamid 
• 60849-54-9 4-(2,6-dichloro-benzoyl)-2,3,5,6-tetramethyl-morpholine 
• 60849-49-2 4-(2,6-dichloro-benzoyl)-2,3,5,6-tetramethyl-morpholine 
• 53083-13-9 2,6-Dichloro-benzoic acid 3-oxo-2-(2,4,6-trimethyl-phenyl)-3H-inden-1-yl ester 
• 66896-85-3 N-Allyl-N-(2,6-dichloro-benzoyl)-benzenesulfonamide 
• 53083-63-9 2,6-Dichloro-benzoic acid 2-(2,6-dichloro-phenyl)-3-oxo-3H-inden-1-yl ester 
• 32709-75-4 2,6-dichlorobenzoylisothiocyanate 
• 68180-40-5 C₁₅H₁₇⁽²⁾HCl₂O₂ 
• 68180-39-2 C₁₅H₁₇⁽²⁾HCl₂O₂ 
• 17847-78-8 2.6-Dichlorbenzoesaeure-(o-nitro-phenylester) 
• 82935-50-0 2,6-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-benzamide 
• 81325-34-0 1-(2,6-dichlorobenzoyl)pyrazole 
• 95883-11-7 1-(2,6-dichlorobenzoyl)-2-formylpyrrole 
• 95883-13-9 1-(2,6-dichlorobenzoyl)-3,5-dimethylpyrazole 

Relevant articles and documents

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