Pentanedioic acid, 2-[(5R)-8-hydroxy-6-oxo-1-[[[(phenylmethoxy)carbonyl]amino]acetyl]-1,7 -diazaspiro[4.4]non-7-yl]-, 1,5-bis(phenylmethyl) ester, (2S)-

Base Information

Chemical Name:Pentanedioic acid, 2-[(5R)-8-hydroxy-6-oxo-1-[[[(phenylmethoxy)carbonyl]amino]acetyl]-1,7 -diazaspiro[4.4]non-7-yl]-, 1,5-bis(phenylmethyl) ester, (2S)-
CAS No.:915958-44-0
Molecular Formula:C36H39N3O9
Molecular Weight:657.72
Hs Code.:

Pentanedioic acid,
2-[(5R)-8-hydroxy-6-oxo-1-[[[(phenylmethoxy)carbonyl]amino]acetyl]-1,7
-diazaspiro[4.4]non-7-yl]-, 1,5-bis(phenylmethyl) ester, (2S)-

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Chemical Property of Pentanedioic acid, 2-[(5R)-8-hydroxy-6-oxo-1-[[[(phenylmethoxy)carbonyl]amino]acetyl]-1,7 -diazaspiro[4.4]non-7-yl]-, 1,5-bis(phenylmethyl) ester, (2S)-

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Technology Process of Pentanedioic acid, 2-[(5R)-8-hydroxy-6-oxo-1-[[[(phenylmethoxy)carbonyl]amino]acetyl]-1,7 -diazaspiro[4.4]non-7-yl]-, 1,5-bis(phenylmethyl) ester, (2S)-

There total 9 articles about Pentanedioic acid, 2-[(5R)-8-hydroxy-6-oxo-1-[[[(phenylmethoxy)carbonyl]amino]acetyl]-1,7 -diazaspiro[4.4]non-7-yl]-, 1,5-bis(phenylmethyl) ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 869001-98-9
dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate

: 915958-44-0
dibenzyl (2S,5'R)-2-[1'-(2''-benzyloxycarbonylamino-acetyl)-8'-hydroxy-6'-oxo-1',7'-diazaspiro[4.4]non-7'-yl]-pentanedioate

Guidance literature:: dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate; With ozone; In methanol; dichloromethane; at -78 ℃; for 0.25h;

With triphenylphosphine; In methanol; dichloromethane; for 24h;
DOI:10.1016/j.tet.2005.08.026

Reference yield:

: 869001-82-1
methyl N-benzyloxycarbonyl-glycyl-L-2-allylprolinate

: 915958-44-0
dibenzyl (2S,5'R)-2-[1'-(2''-benzyloxycarbonylamino-acetyl)-8'-hydroxy-6'-oxo-1',7'-diazaspiro[4.4]non-7'-yl]-pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / aqueous sodium hydroxide / dioxane / 20 h / 20 °C

2.1: 76 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 19.5 h / 20 °C

3.1: ozone / CH₂Cl₂; methanol / 0.25 h / -78 °C

3.2: 63 percent / triphenylphosphine / CH₂Cl₂; methanol / 24 h

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; ozone; triethylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.tet.2005.08.026

Reference yield:

: 869001-88-7
N-benzyloxycarbonyl-glycyl-L-2-allylproline

: 915958-44-0
dibenzyl (2S,5'R)-2-[1'-(2''-benzyloxycarbonylamino-acetyl)-8'-hydroxy-6'-oxo-1',7'-diazaspiro[4.4]non-7'-yl]-pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 19.5 h / 20 °C

2.1: ozone / CH₂Cl₂; methanol / 0.25 h / -78 °C

2.2: 63 percent / triphenylphosphine / CH₂Cl₂; methanol / 24 h

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; ozone; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.tet.2005.08.026