869001-98-9

Basic information

• Product Name: dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate
• Synonyms: dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate
• CAS NO: 869001-98-9
• Molecular Weight: 655.748
• Mol File: 869001-98-9.mol

Chemical Properties

• CAS DataBase Reference: dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate(869001-98-9)
• EPA Substance Registry System: dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate(869001-98-9)

Safety Data

• Hazardous Substances Data: 869001-98-9(Hazardous Substances Data)

Upstream product

• 869001-88-7 N-benzyloxycarbonyl-glycyl-L-2-allylproline 
• 2791-84-6 L-glutamic acid dibenzyl ester 4-toluenesulfonate 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 900159-03-7 2-allyl-N-Boc-L-Pro-Glu(OBn)-OBn 
• 144085-23-4 N-tert-butoxycarbonyl-L-α-allylproline 
• 869001-82-1 methyl N-benzyloxycarbonyl-glycyl-L-2-allylprolinate 
• 133010-18-1 Z-glycine fluoride 
• 118916-60-2 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one 
• 220200-87-3 (2R,5R)-5-(2-propenyl)-2-trichloromethyl-1-aza-3-oxabicyclo-[3.3.0]octane-4-one 
• 147-85-3 L-proline 

Downstream Products

• 869002-11-9 dibenzyl (2S,5'R)-2-[1'-(2''-benzyloxycarbonylamino-acetyl)-6'-oxo-1',7'-diazaspiro[4.4]non-7'-yl]-pentanedioate 
• 915958-44-0 dibenzyl (2S,5'R)-2-[1'-(2''-benzyloxycarbonylamino-acetyl)-8'-hydroxy-6'-oxo-1',7'-diazaspiro[4.4]non-7'-yl]-pentanedioate 

Relevant articles and documents

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity

The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not dir

Synthesis of proline-modified analogues of the neuroprotective agent glycyl-L-prolyl-glutamic acid (GPE)

The synthesis of ten proline-modified analogues of the neuroprotective tripeptide GPE is described. Five of the analogues incorporate a proline residue with a hydrophobic group at C-2 and two further analogues have this side chain locked into a spirolactam ring system. The pyrrolidine ring was also modified by replacing the γ-CH2 group with sulfur and/or incorporation of two methyl groups at C-5.