Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 5-(dimethylphenylsilyl)-, 2-methyl
1-(phenylmethyl) ester, (2S)-
There total 3 articles about 1,2-Pyrrolidinedicarboxylic acid, 5-(dimethylphenylsilyl)-, 2-methyl
1-(phenylmethyl) ester, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenyldimethylsilyl chloride;
With
lithium;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
With
copper(l) cyanide;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
for 0.166667h;
5-benzenesulfonylpyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl ester;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 1.5h;
DOI:10.1021/ja064737l
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 85 percent / magnesium sulfate; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
2.1: lithium / tetrahydrofuran / 12 h / 20 °C
2.2: copper cyanide / tetrahydrofuran; diethyl ether / 0.17 h / 20 °C
2.3: 71 percent / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C
With
lithium; magnesium sulfate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja064737l
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 85 percent / magnesium sulfate; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
2.1: lithium / tetrahydrofuran / 12 h / 20 °C
2.2: copper cyanide / tetrahydrofuran; diethyl ether / 0.17 h / 20 °C
2.3: 71 percent / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C
With
lithium; magnesium sulfate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja064737l
