214072-10-3

Upstream product

• 67-56-1 methanol 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 75857-94-2 (5S)-N-(benzyloxycarbonyl)-5-methoxycarbonyl-2-pyrrolidinone 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 147-85-3 L-proline 
• 501-53-1 benzyl chloroformate 
• 93271-97-7 1-benzyl 2-methyl (2S)-5-hydroxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 116894-75-8 (2S,5R)-5-(1-Benzyloxycarbonyl-2-oxo-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 116894-75-8 (2S,5S)-5-(1-Benzyloxycarbonyl-2-oxo-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 916049-27-9 1-(2-tert-butoxycarbonylamino-3-phenylpropionyl)-5-(dimethylphenylsilyl)pyrrolidine-2-carboxylic acid methyl ester 
• 916049-26-8 5-(dimethylphenylsilyl)pyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl ester 
• 916049-28-0 1-(2-tert-butoxycarbonylamino-3-hydroxypropionyl)-5-(dimethylphenylsilyl)pyrrolidine-2-carboxylic acid methyl ester 
• 916049-29-1 5-(dimethylphenylsilyl)-1-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pent-4-enoyl]pyrrolidine-2-carboxylic acid methyl ester 
• 429684-95-7 1-(2-tert-butoxycarbonylamino-3-phenylpropionyl)-5-methoxypyrrolidine-2-carboxylic acid methyl ester 
• 1335012-32-2 diethyl [(5S)-N-benzyloxycarbonyl-(2S)-methoxycarbonylpyrrolidin-5-yl]phosphonate 
• 1335012-30-0 dimethyl [(5S)-N-benzyloxycarbonyl-(2S)-methoxycarbonylpyrrolidin-5-yl]phosphonate 
• 1346907-15-0 diethyl ((2S)-N-benzyloxycarbonylpyrrolidin-2-yl)phosphonate 
• 1346907-17-2 diethyl [N-benzoyl-(2S)-methoxycarbonylpyrrolidin-5-yl]phosphonate 
• 1335012-35-5 di-n-butyl [(5S)-N-benzyloxycarbonyl-(2S)-methoxycarbonylpyrrolidin-5-yl]phosphonate 
• 1335012-33-3 diisopropyl [(5S)-N-benzyloxycarbonyl-(2S)-methoxycarbonylpyrrolidin-5-yl]phosphonate 
• 1335012-34-4 diphenyl [(5S)-N-benzyloxycarbonyl-(2S)-methoxycarbonylpyrrolidin-5-yl]phosphonate 

Relevant academic research and scientific papers

BETA-HYDROXY HETEROCYCLIC AMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA

There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1, ring A, m and n have meanings as provided in the description.

Synthesis of highly functionalized 2,5-disubstituted pyrrolidines via an aza-Morita-Baylis-Hillman-type reaction

An aza-Morita-Baylis-Hillman-type reaction of Michael acceptors with 5-substituted cyclic N,O-acetals derived from pyrrolidines has been investigated. It has been found that the combination of Me2S and TMSOTf work well with unhindered and reactive enals and enones whilst the use of quinuclidine and TMSOTf is superior for more hindered Michael acceptors. The reactions lead to 2,5-trans-disubstituted pyrrolidines with good to excellent diastereoselectivity. The origin of the selectivity is discussed.

Synthesis of indolizidines (-)-195B, (-)-223AB and (-)-239AB: (2S,5R)- l-[(benzyloxy)carbonyl]-2-methoxycarbonyl-5-(4pentenyl)pyrrolidine as a versatile chiral building block

The total syntheses of three levogyre 3,5-disubstituted indolizidines, (-)-195B, (-)-223AB and (-)-239AB are described. The employed strategy is based on the utilization of the common enantiopure trans 2,5-disubstituted pyrrolidine 3, which is assembled b

Oxidation of L-Proline Methyl Ester Derivatives with the Iodosylbenzene/Trimethylsilylazide Reagent Combination

Oxidation of a series of L-Proline derivatives with the (PhIO)n/TMSN3 reagent combination is reported.Subsequent utilization of the 5-azido N-acyl functionality as a N-acyl iminium ion precursor is described.

A short and highly stereocontrolled total synthesis of (3R,5R,8aR)-3-n-Butyl-5-methylindolizidine

Total synthesis of (-) (3R,5R,8aR)-3-n-Butyl-5-methylindolizidine is described in 9 steps (22% overall yield) from L-proline.

SYNTHESIS OF (6S,8R)-6-(1'-HYDROXYETHYL)CARBAPENEM, A THIENAMYCIN TYPE

Title carbapenem (1) having thienamycin-type of side chain at C-6 was synthesized from L-glutamic acid.Chirospecific oxymercuration of 6-vinylcarbapenam (12a) successfully induced 8R-hydroxyl.

Enantioselective Synthesis of the Carbapenem Ring System from (S)-proline

Enantioselective synthesis of (+)-PS-5 via stereoselective alkylation of proline derivatives is described.