Dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate

Base Information

• Chemical Name: Dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate
• CAS No.: 27525-74-2
• Molecular Formula: C11H13 N O4
• Molecular Weight: 223.229
• Hs Code.: 2933399090
• European Community (EC) Number: 248-509-9
• DSSTox Substance ID: DTXSID60181945
• Nikkaji Number: J250.530D
• Wikidata: Q83052598
• Mol file: 27525-74-2.mol

Synonyms:27525-74-2;Dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate;EINECS 248-509-9;2,6-dimethyl-pyridine-3,5-dicarboxylic acid dimethyl ester;3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-, 3,5-dimethyl ester;Oprea1_364199;SCHEMBL4174949;DTXSID60181945;HMS1579C13;AKOS000313802;3,5-dimethoxycarbonyl-2,6-dimethylpyridine;SR-01000459851;SR-01000459851-1;2,6-Dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester

Chemical Property of Dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate

Chemical Property:

• Vapor Pressure: 0.00512mmHg at 25°C
• Melting Point: 101-102 °C
• Boiling Point: 275.4°Cat760mmHg
• PKA: 2.60±0.20(Predicted)
• Flash Point: 120.3°C
• PSA: 65.49000
• Density: 1.168g/cm³
• LogP: 1.27160
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 223.08445790
• Heavy Atom Count: 16
• Complexity: 253

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C(=N1)C)C(=O)OC)C(=O)OC

Technology Process of Dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate

There total 34 articles about Dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydropyridine (17438-14-1) → dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate (27525-74-2)

Guidance literature:

With oxygen; isobutyraldehyde; C₃₉H₄₅N₁₂O₃Fe; In 1,2-dichloro-ethane; at 20 ℃; for 72h; under 760 Torr;

DOI:10.1016/S0040-4039(00)61720-3

Reference yield: 99.0%

dimethyl 4-benzyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (103026-74-0) → dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate (27525-74-2)

Guidance literature:

With urea-hydrogen peroxide; iodine; In ethyl acetate; at 20 ℃; for 5h;

DOI:10.1016/j.tet.2008.04.040

Reference yield: 99.0%

dimethyl 1,4-dihydro-4-(1-methylethyl)-2,6-dimethyl-3,5-pyridinedicarboxylate (103026-75-1) → dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate (27525-74-2)

Guidance literature:

With urea-hydrogen peroxide; iodine; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2008.04.040

upstream raw materials:

4-formyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one

methyl 3-aminocrotonate

3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine

2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydropyridine

Downstream raw materials:

2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine

3-carbomethoxy-5-(chloromethyl)-2,6-dimethylpyridine

N,N'-dimethyl 5,15-diaza<2₄>(1,2,4,5)cyclophanebis(onium) bis(p-toluenesulfonate)

N,N'-dimethyl 5,12-diaza<2₄>(1,2,4,5)cyclophanebis(onium) bis(p-toluenesulfonate)