1-Piperidinecarboxylic acid, 4-formyl-, methyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-formyl-, methyl ester
• CAS No.: 916078-41-6
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.196
• Mol file: 916078-41-6.mol

Synonyms:methyl 4-formylpiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-formyl-, methyl ester;4-formylpiperidine-1-carboxylic acid methyl ester;

Chemical Property of 1-Piperidinecarboxylic acid, 4-formyl-, methyl ester

Chemical Property:

• Boiling Point: 259.5±33.0 °C(Predicted)
• PKA: -2.20±0.40(Predicted)
• PSA: 46.61000
• Density: 1.208±0.06 g/cm3(Predicted)
• LogP: 0.60160

Purity/Quality:

97% ^*data from raw suppliers

1-Piperidinecarboxylicacid,4-formyl-,methylester >96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-formyl-, methyl ester

There total 4 articles about 1-Piperidinecarboxylic acid, 4-formyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 4-(hydroxymethyl)piperidine-1-carboxylate (916078-39-2) → N-methoxycarbonylpiperidine-4-carboxaldehyde (916078-41-6)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; sodium bromide; In dichloromethane; water; at 0 - 10 ℃; for 1.25h;

Reference yield:

methyl 4-(hydroxymethyl)piperidine-1-carboxylate (916078-39-2) → N-methoxycarbonylpiperidine-4-carboxaldehyde (916078-41-6) + 1-(methoxycarbonyl)piperidine-4-carboxylic acid (197585-42-5)

Guidance literature:

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In water; at 20 ℃; for 24h; Green chemistry;

DOI:10.1039/d0gc03316b

Reference yield:

4-piperidinemethanol (6457-49-4) → N-methoxycarbonylpiperidine-4-carboxaldehyde (916078-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water / 20 °C / Green chemistry

2: 4-methyl-2,2,6,6-tetramethyl-piperidine oxide; [bis(acetoxy)iodo]benzene / water; tetrahydrofuran / 20 °C / Green chemistry

With 4-methyl-2,2,6,6-tetramethyl-piperidine oxide; [bis(acetoxy)iodo]benzene; potassium carbonate; In tetrahydrofuran; water;

DOI:10.1039/d0gc03316b

upstream raw materials:

methyl 4-(hydroxymethyl)piperidine-1-carboxylate

ethyl 1-methoxycarbonyl-4-piperidinecarboxylate

4-piperidinemethanol

Downstream raw materials:

C₂₇H₂₉N₅O₂