11βH,13-Dihydroparthenolide

Base Information

• Chemical Name: 11βH,13-Dihydroparthenolide
• CAS No.: 2513-76-0
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.338
• Mol file: 2513-76-0.mol

Synonyms:Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one,2,3,6,7,7a,8,10a,10b-octahydro-1a,5,8-trimethyl-,[1aR-(1aR*,4E,7aS*,8S*,10aS*,10bR*)]-; Parthenolide, dihydro- (6CI,7CI,8CI);11,13-Dihydroparthenolide; 11bH,13-Dihydroparthenolide; Dihydroparthenolide

Chemical Property of 11βH,13-Dihydroparthenolide

Chemical Property:

• Vapor Pressure: 4.43E-06mmHg at 25°C
• Melting Point: 137-139 °C
• Boiling Point: 383.3°Cat760mmHg
• Flash Point: 161.3°C
• PSA: 38.83000
• Density: 1.065g/cm³
• LogP: 2.84190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11βH,13-Dihydroparthenolide

There total 6 articles about 11βH,13-Dihydroparthenolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(-)-parthenolide → dihydroparthenolide (2513-76-0) + 9β-hydroxy-11βH-dihydroparthenolide

Guidance literature:

With dipotassium hydrogenphosphate; D-glucose; Streptomyces fulvissimus NRRL 1453B; glycerol; sodium chloride; peptone; yeast extract; In water; acetone; for 144h;

DOI:10.1016/S0031-9422(99)00066-7

Reference yield: 13.0%

(-)-parthenolide → dihydroparthenolide (2513-76-0) + 11αH-dihydroparthenolide + 14-hydroxy-11βH-dihydroparthenolide

Guidance literature:

With dipotassium hydrogenphosphate; D-glucose; Rhizopus nigricans NRRL 1477; glycerol; sodium chloride; peptone; yeast extract; In water; acetone; for 144h;

DOI:10.1016/S0031-9422(99)00066-7

Reference yield:

→ (11S)-4,5ξ-epoxy-6α-hydroxy-4ξH-germacr-1(10)t-en-12-oic acid-lactone (2513-76-0)

Guidance literature:

With methanol; platinum; Hydrogenation;

upstream raw materials:

methanol

4,5ξ-epoxy-6α-hydroxy-4ξH-germacra-1(10)t,11(13)-dien-12-oic acid-lactone

Refernces

• 1、 Galal, Ahmed M.,Ibrahim, Abdel-Rahim S.,Mossa, Jaber S.,El-Feraly, Farouk S.. "Microbial transformation of parthenolide". . p. 761 - 765. Retrieved 1999.