Phospholane, 1-[2-(diphenylphosphino)ethyl]-2,5-dimethyl-, (2R,5R)-

Base Information

• Chemical Name: Phospholane, 1-[2-(diphenylphosphino)ethyl]-2,5-dimethyl-, (2R,5R)-
• CAS No.: 916162-09-9
• Molecular Formula: C20H26P2
• Molecular Weight: 328.374
• Mol file: 916162-09-9.mol

Synonyms:

Chemical Property of Phospholane, 1-[2-(diphenylphosphino)ethyl]-2,5-dimethyl-, (2R,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phospholane, 1-[2-(diphenylphosphino)ethyl]-2,5-dimethyl-, (2R,5R)-

There total 2 articles about Phospholane, 1-[2-(diphenylphosphino)ethyl]-2,5-dimethyl-, (2R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-diphenylphosphino-2-phosphinoethane (34664-50-1) + (4S,7S)-4,7-dimethyl-1,3,2-dioxathiepane 2,2-dioxide (220224-82-8) → 1-[(2'R,5'R)-2',5'-dimethylphospholano]-2-(diphenylphosphino)ethane (916162-09-9)

Guidance literature:

1-diphenylphosphino-2-phosphinoethane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

(4S,7S)-4,7-dimethyl-1,3,2-dioxathiepane 2,2-dioxide; In tetrahydrofuran; hexane; at 0 - 20 ℃;

DOI:10.1039/b607479k

Reference yield:

1-diethylphosphonato-2-(diphenylphosphino)ethane (34664-51-2) → 1-[(2'R,5'R)-2',5'-dimethylphospholano]-2-(diphenylphosphino)ethane (916162-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 57 percent / LiAlH₄ / diethyl ether / 20 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

2.2: 85 percent / tetrahydrofuran; hexane / 0 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1039/b607479k

Reference yield: 85.0%

1-[(2'R,5'R)-2',5'-dimethylphospholano]-2-(diphenylphosphino)ethane (916162-09-9) + dichloro( 1,5-cyclooctadiene)platinum(ll) (12080-32-9) → [PtCl2(1-[(2'R,5'R)-2',5'-dimethylphospholano]-2-(diphenylphosphino)ethane)]

Guidance literature:

In toluene; under N2 atm. to suspn. Pt complex in toluene soln. ligand in toluene was added and stirred at room temp. for 2 h; volatiles were removed in vacuo, residue was washed with Et2O, ppt. was filtered and dried in vacuo; elem. anal.;

DOI:10.1039/b607479k

upstream raw materials:

1-diphenylphosphino-2-phosphinoethane

(4S,7S)-4,7-dimethyl-1,3,2-dioxathiepane 2,2-dioxide

1-diethylphosphonato-2-(diphenylphosphino)ethane