6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrate

Base Information

Chemical Name:6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrate
CAS No.:83948-21-4
Molecular Formula:C₂₅H₃₂N₄O
Molecular Weight:404.555
Hs Code.:
DSSTox Substance ID:DTXSID20232846
Nikkaji Number:J1.537.011D
Wikidata:Q83114034
ChEMBL ID:CHEMBL55137

Synonyms:CHEMBL55137;1-((3-(Diethylamino)propyl)amino)-5,6,11-trimethyl-6H-pyrido(4,3-b)carbazol-9-ol hydrate;6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrate;83948-21-4;C25H32N4O.H2O;SCHEMBL12387166;DTXSID20232846;BDBM50174408;C25-H32-N4-O.H2-O;LS-133323;1-(3-Diethylamino-propylamino)-5,6,11-trimethyl-6H-pyrido[4,3-b]carbazol-9-ol;1-[[3-(Diethylamino)propyl]amino]-5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole-9-ol

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrate

Chemical Property:

Vapor Pressure:1.02E-16mmHg at 25°C
Boiling Point:634.9°Cat760mmHg
Flash Point:337.8°C
Density:1.17g/cm³
XLogP3:5.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:404.25761166
Heavy Atom Count:30
Complexity:555

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CCCNC1=NC=CC2=C(C3=C(C(=C21)C)C4=C(N3C)C=CC(=C4)O)C

Technology Process of 6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrate

There total 5 articles about 6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 83947-98-2
1-chloro-9-(benzoyloxy)-5,6,11-trimethyl-6H-pyrido<4,3-b>carbazole

: 104-78-9
diethylaminopropylamine

: 83948-21-4
1-(3-diethylamino-propylamino)-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol

Guidance literature:: at 160 ℃; for 3h;
DOI:10.1021/jm00356a012

Reference yield:

: 83947-93-7
9-hydroxy-5,11-dimethoxy-6H-pyrido<4,3-b>carbazol-1(2H)-one

: 83948-21-4
1-(3-diethylamino-propylamino)-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / pyridine / 1 h / Heating

2: 72 percent / phosphorus oxychloride / 3 h / Heating

3: 1.) NaH / 1.) dimethylacetamide, -15 deg C, 30 min, 2.) dimethylacetamide, -15 deg C, 15 h

4: 68 percent / 3 h / 160 °C

With pyridine; sodium hydride; trichlorophosphate;
DOI:10.1021/jm00356a012

Reference yield:

: 83947-94-8
9-(benzoyloxy)-5,11-dimethyl-6H-pyrido<4,3-b>carbazol-1(2H)-one

: 83948-21-4
1-(3-diethylamino-propylamino)-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / phosphorus oxychloride / 3 h / Heating

2: 1.) NaH / 1.) dimethylacetamide, -15 deg C, 30 min, 2.) dimethylacetamide, -15 deg C, 15 h

3: 68 percent / 3 h / 160 °C

With sodium hydride; trichlorophosphate;
DOI:10.1021/jm00356a012