104-78-9 Usage
Chemical Properties
clear colorless to slightly yellowish liquid
Uses
Different sources of media describe the Uses of 104-78-9 differently. You can refer to the following data:
1. Curing agent for epoxy resins, intermediate.
2. 3-Diethylaminopropylamine is used as a solvent, extraction agents and organic synthesis intermediates, dyes, pigments, surface active agent.
3. 3-(Diethylamino)propylamine may be used in the preparation of:Biocompatible polyampholyte-coated (poly(acrylic acid)-co-3-(diethylamino)-propylamine magnetite nanoparticles (PAMNPs).Hyaluronic acid grafted with 3-diethylaminopropyl (DEAP) group (HA-g-DEAP) nanoparticles for use as a drug delivery vehicle.DEAPA-modified poly(vinyl alcohol) (PVA) polymers that can be employed in gene silencing.It may also be used to introduce cationic groups during the surface modification of microfibrillated cellulose (MFC).
General Description
A water-white liquid with a fishlike odor. Flash point 138°F. May be very irritating to skin and eyes. Used to make other chemicals and as a component of adhesives.
Air & Water Reactions
Flammable.
Reactivity Profile
3-Diethylaminopropylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Hazard
Moderate fire risk. Irritant to skin.
Health Hazard
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Moderately toxic by
ingestion and skin contact. Corrosive to the
eyes, skin, and mucous membranes. A
sensitizer. See also AMINES. Flammable
liquid when exposed to heat or flame; can
react with oxidzing materials. To fight fire,
use foam, CO2, dry chemical. When heated
to decomposition it emits toxic fumes of
NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 104-78-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104-78:
(5*1)+(4*0)+(3*4)+(2*7)+(1*8)=39
39 % 10 = 9
So 104-78-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H18N2/c1-3-9(4-2)7-5-6-8/h3-8H2,1-2H3/p+2
104-78-9Relevant articles and documents
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Utermohlen,Hamilton
, p. 156,158 (1941)
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New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis
Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale
, p. 304 - 317 (2019/02/07)
Cdc2-like kinase 1 (CLK1) and dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) are involved in the regulation of alternative pre-mRNA splicing. Dysregulation of this process has been linked to cancer progression and neurodegenerative diseases, making CLK1 and DYRK1A important therapeutic targets. Here we describe the synthesis of new pyrido[3,4-g]quinazoline derivatives and the evaluation of the inhibitory potencies of these compounds toward CDK5, CK1, GSK3, CLK1 and DYRK1A. Introduction of aminoalkylamino groups at the 2-position resulted in several compounds with low nanomolar affinity and selective inhibition of CLK1 and/or DYRK1A. Their evaluation on several immortalized or cancerous cell lines showed varying degree of cell viability reduction. Co-crystal structures of CLK1 with two of the most potent compounds revealed two alternative binding modes of the pyrido[3,4-g]quinazoline scaffold that can be exploited for future inhibitor design.
Highly efficient reduction of carbonyls, azides, and benzyl halides by NaBH4 in water catalyzed by PANF-immobilized quaternary ammonium salts
Du, Jianguo,Xu, Gang,Lin, Huikun,Wang, Guangwei,Tao, Minli,Zhang, Wenqin
supporting information, p. 2726 - 2735 (2016/05/24)
A series of polyacrylonitrile fiber-supported quaternary ammonium salts (PANF-QAS) were prepared and applied to the catalytic reduction of aldehydes, ketones, azides, and benzyl halides in water using NaBH4 as the reducing reagent in a highly efficient, economic, and environmentally benign way. The structure-activity relationships were investigated, which showed that the catalysts made up of quaternary ammonium salts with longer alkyl chains, larger cationic radii and better lipophilicity speed up the reduction reaction to afford the products in excellent yield. Moreover, the optimized catalyst can be applied to the reduction of 1-naphthaldehyde in a continuous flow process with outstanding reactivity and recyclability.
