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Technology Process of Ribonuclease A

Ribonuclease A

Base Information
  • Chemical Name:Ribonuclease A
  • CAS No.:9001-99-4
  • Molecular Formula:C9H14N4O3
  • Molecular Weight:226.23246
  • Hs Code.:35079090
Ribonuclease A

Synonyms:Ribonuclease

Suppliers and Price of Ribonuclease A
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Ribonuclease A
  • 10ug
  • $ 316.00
  • Usbiological
  • Ribonuclease A, Bovine Pancreas
  • 100mg
  • $ 87.00
  • Usbiological
  • Ribonuclease A
  • 96Tests
  • $ 809.00
  • Usbiological
  • Ribonuclease A
  • 10ug
  • $ 356.00
  • Usbiological
  • Ribonuclease A
  • 10ug
  • $ 343.00
  • Usbiological
  • Ribonuclease A
  • 10ug
  • $ 339.00
  • Usbiological
  • Ribonuclease A, Bovine Pancreas
  • 100mg
  • $ 573.00
  • Usbiological
  • Ribonuclease A
  • 96Tests
  • $ 895.00
  • Sigma-Aldrich
  • Ribonuclease A from bovine pancreas Type I-AS, 50-100 Kunitz units/mg protein
  • 10g
  • $ 2820.00
  • Sigma-Aldrich
  • Ribonuclease A from bovine pancreas Type I-A, powder, ≥60% RNase A basis (SDS-PAGE), ≥50 Kunitz units/mg protein
  • 5g
  • $ 1810.00
Total 98 raw suppliers
Chemical Property of Ribonuclease A
Chemical Property:
  • Appearance/Colour:White to white with a yellow cast powder 
  • Melting Point:243 °C (dec.) 
  • PSA：0.00000 
  • LogP:0.00000 
  • Storage Temp.:2-8°C 
  • Sensitive.:Moisture Sensitive 
  • Solubility.:Reconstitute in 10mM acetate, pH 5.0 with or without 15mM calciu 
  • Water Solubility.:Soluble in water. 
Purity/Quality:

99% *data from raw suppliers

Ribonuclease A *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 22-24/25 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • General Description Ribonuclease A (RNase A) inhibition is enhanced by resorcinol and phloroglucinol derivatives of catechin and epicatechin, with increased phenolic hydroxyl groups playing a critical role in improving inhibitory activity. These derivatives demonstrate stronger ribonucleolytic inhibition compared to their parent compounds and also exhibit anti-angiogenic effects by suppressing angiogenin-induced angiogenesis.
Refernces

Synthesis and ribonuclease A inhibition activity of resorcinol and phloroglucinol derivatives of catechin and epicatechin: Importance of hydroxyl groups

10.1016/j.bmc.2010.06.077

The research discusses the synthesis and inhibitory activity of resorcinol and phloroglucinol derivatives of catechin and epicatechin against ribonuclease A (RNase A), with the aim of increasing the number of phenolic hydroxyl groups to enhance inhibition. The study concluded that these novel conjugates were more effective inhibitors of RNase A than catechin and epicatechin, highlighting the importance of phenolic hydroxyl groups in inhibiting ribonucleolytic activity. The research also explored the compounds' anti-angiogenic activity through the chorioallantoic membrane (CAM) assay, finding that the epicatechin-based polyphenols showed inhibition of angiogenin-induced angiogenesis. Chemicals used in the synthesis process included (+)-catechin, (-)-epicatechin, phloroglucinol, resorcinol, LiBr, and various protecting groups such as benzyl ether. The study employed techniques like fluorescence studies, protein-ligand docking, and CD spectroscopic studies to evaluate binding parameters and interactions.

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