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| CAS No.: | 9001-99-4 |
|---|---|
| Name: | Ribonuclease A |
| Molecular Structure: | |
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| Formula: | C9H14N4O3 |
| Molecular Weight: | 226.23246 |
| Synonyms: | Ribonuclease |
| EINECS: | 232-646-6 |
| Melting Point: | 243 °C (dec.) |
| Solubility: | Soluble in water. |
| Appearance: | White to white with a yellow cast powder |
| Safety: | 22-24/25 |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Chemistry
Molecular Formula: C9H14N4O3
Molecular Weight: 226.2325
EINECS: 207-332-7
Density: 1.375 g/cm3
Melting Point: 243 °C (dec.)
Flash Point: 350.7 °C
Boiling Point: 656.2 °C at 760 mmHg
Vapour Pressure: 4.08E-18 mmHg at 25 °C
Enthalpy of Vaporization: 101.53 kJ/mol
Storage temp.: 2-8 °C
Structure of Ribonuclease A (CAS NO.9001-99-4):
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IUPAC Name: 2-(3-Aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
Canonical SMILES: C1=C(NC=N1)CC(C(=O)O)NC(=O)CCN
InChI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)
InChIKey: CQOVPNPJLQNMDC-UHFFFAOYSA-N
History
The importance of bovine pancreatic Ribonuclease A (CAS NO.9001-99-4) was secured when the Armour & Co. (of hot dog fame) purified a kilogram of it, and gave 10 mg samples away free to any interested scientists. The ability to have a single lot of purified enzyme instantly made RNase the model system for protein studies.Ribonuclease-S, which is RNase A that has been treated with subtilisin, was the third protein to have its structure solved, in 1967. Studies of the oxidative folding of RNase A led Chris Anfinsen to enunciate the thermodynamic hypothesis of protein folding, which states that the folded form of a protein represents the minimum of its free energy.
Uses
Ribonuclease A (CAS NO.9001-99-4) is used for biochemical research.
Production
Ribonuclease A (CAS NO.9001-99-4) can be obtained from the fermentation broth of the grate produced by erythromycin.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 355mg/kg (355mg/kg) | "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985. | |
| mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985. | |
| mouse | LD50 | subcutaneous | 230mg/kg (230mg/kg) | "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985. | |
| rat | LD50 | intramuscular | 310mg/kg (310mg/kg) | "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985. | |
| rat | LD50 | intraperitoneal | 392mg/kg (392mg/kg) | "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985. | |
| rat | LD50 | subcutaneous | 290mg/kg (290mg/kg) | "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985. |
Safety Profile
Safety Statements:
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: RF0760000
F 10: Keep under argon.
F 21: Sensitive to humidity.
Specification
Ribonuclease A , its cas register number is 9001-99-4. It also can be called Alkaline ribonuclease ; Amphinase ; Pancreatic ribonuclease ; RNase; Ribonuclease ; S-RNase ; and Ribonucleic phosphatase .