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4-Chlorophenylboronic acid

Base Information Edit
  • Chemical Name:4-Chlorophenylboronic acid
  • CAS No.:1679-18-1
  • Molecular Formula:C6H6BClO2
  • Molecular Weight:156.376
  • Hs Code.:29319090
  • European Community (EC) Number:216-845-5
  • NSC Number:25408
  • UNII:AB2T8N4T4C
  • DSSTox Substance ID:DTXSID50168427
  • Nikkaji Number:J54.863D
  • Wikipedia:4-chlorophenylboronic acid
  • Wikidata:Q69757145
  • ChEMBL ID:CHEMBL1209679
  • Mol file:1679-18-1.mol
4-Chlorophenylboronic acid

Synonyms:p-Chlorophenylboronic acid;(4-chlorophenyl)boronic acid;Boronic acid, (4-chlorophenyl)-;p-Chlorobenzeneboronic acid;

Suppliers and Price of 4-Chlorophenylboronic acid
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • 4-Chlorophenylboronic acid
  • 25g
  • $ 340.00
  • TRC
  • 4-ChlorobenzeneboronicAcid
  • 500g
  • $ 525.00
  • TCI Chemical
  • 4-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
  • 5g
  • $ 48.00
  • TCI Chemical
  • 4-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
  • 25g
  • $ 140.00
  • Synthonix
  • 4-Chlorophenylboronic acid 98%
  • 100g
  • $ 70.00
  • Synthonix
  • 4-Chlorophenylboronic acid 98%
  • 5g
  • $ 15.00
  • Synthonix
  • 4-Chlorophenylboronic acid 98%
  • 10g
  • $ 20.00
  • Synthonix
  • 4-Chlorophenylboronic acid 98%
  • 25g
  • $ 25.00
  • Synthonix
  • 4-Chlorophenylboronic acid 98%
  • 500g
  • $ 280.00
  • SynQuest Laboratories
  • 4-Chlorobenzeneboronic acid 98%
  • 500 g
  • $ 317.00
Total 226 raw suppliers
Chemical Property of 4-Chlorophenylboronic acid Edit
Chemical Property:
  • Appearance/Colour:off-white to beige crystalline powder 
  • Vapor Pressure:0.000693mmHg at 25°C 
  • Melting Point:284-289 °C(lit.) 
  • Refractive Index:1.557 
  • Boiling Point:295.4 °C at 760 mmHg 
  • PKA:8.39±0.10(Predicted) 
  • Flash Point:132.4 °C 
  • PSA:40.46000 
  • Density:1.32 g/cm3 
  • LogP:0.01980 
  • Storage Temp.:Refrigerator (+4°C) 
  • Solubility.:DMSO 
  • Water Solubility.:2.5 g/100 mL 
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:1
  • Exact Mass:156.0149373
  • Heavy Atom Count:10
  • Complexity:102
Purity/Quality:

99.5% *data from raw suppliers

4-Chlorophenylboronic acid *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn,IrritantXi 
  • Hazard Codes:Xn,Xi 
  • Statements: 20/21/22-36/37/38 
  • Safety Statements: 36-37/39-26 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:B(C1=CC=C(C=C1)Cl)(O)O
  • Uses suzuki reaction 4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones. 4-Chlorophenylboronic acid can be used as a reactant in:Palladium-catalyzed direct arylation.Cyclopalladation. Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation. Copper-mediated ligandless aerobic fluoroalkylation. Pd-catalyzed arylative cyclization. Ruthenium catalyzed direct arylation. Ligand-free copper-catalyzed coupling reactions. Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions. It can also be used to prepare: Substituted diarylmethylidenefluorenes via Suzuki coupling reaction.Baclofen lactam by Suzuki coupling of a pyrrolinyl tosylate, followed by hydrogenation reaction.Palladium(II) thiocarboxamide complexes as Suzuki coupling catalysts. Biaryls by Suzuki reactions of aryl chlorides, bromides, and iodides with arylboronic acids.
Technology Process of 4-Chlorophenylboronic acid

There total 35 articles about 4-Chlorophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
4-chlorophenyl trifluoromethanesulfonate; With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; diisopropopylaminoborane; triethylamine; triphenylphosphine; In tetrahydrofuran; at 65 ℃; for 12h; Inert atmosphere;
With methanol; In tetrahydrofuran; at 0 ℃; Further stages; Inert atmosphere;
DOI:10.1016/j.tet.2010.11.065
Guidance literature:
para-dichlorobenzene; With iodine; magnesium; In tetrahydrofuran; toluene; at 60 - 65 ℃; for 2h; Inert atmosphere;
Trimethyl borate; In tetrahydrofuran; toluene; at -20 - -15 ℃; for 2h; Solvent; Reagent/catalyst; Temperature;
Guidance literature:
para-dichlorobenzene; With iodine; magnesium; In tetrahydrofuran; toluene; at 60 - 65 ℃; for 0.5h; Inert atmosphere;
boric acid tributyl ester; In tetrahydrofuran; toluene; at -20 - -15 ℃; for 2h;
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