cis-Tranilast

Base Information

Chemical Name:cis-Tranilast
CAS No.:91920-58-0
Molecular Formula:C₁₈H₁₇NO₅
Molecular Weight:327.337
Hs Code.:
DSSTox Substance ID:DTXSID30424972
Nikkaji Number:J511.890E
Wikidata:Q82237724
ChEMBL ID:CHEMBL1474479
Mol file:91920-58-0.mol

Synonyms:cis-Tranilast;91920-58-0;2-[[(Z)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid;Tocris-1098;Lopac-T-0318;CHEMBL1474479;SCHEMBL10978582;DTXSID30424972;(Z)-2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid;2-[[(2Z)-3-(3,4-Dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]benzoic Acid;NCGC00015995-01;NCGC00018185-01;NCGC00018185-02;NCGC00018185-03;NCGC00021458-02

Suppliers and Price of cis-Tranilast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
cis-Tranilast
10mg
$ 990.00

TRC
cis-Tranilast
1mg
$ 140.00

Total 5 raw suppliers

Chemical Property of cis-Tranilast

Chemical Property:

Melting Point:138-141°C
Boiling Point:585.6±50.0 °C(Predicted)
PKA:3.45±0.36(Predicted)
PSA：88.35000
Density:1.299±0.06 g/cm3(Predicted)
LogP:3.70340
Storage Temp.:Amber Vial, -20°C Freezer
Solubility.:Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:327.11067264
Heavy Atom Count:24
Complexity:464

Purity/Quality:

97% ^*data from raw suppliers

cis-Tranilast ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC
Isomeric SMILES:COC1=C(C=C(C=C1)/C=C\C(=O)NC2=CC=CC=C2C(=O)O)OC
Uses cis-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.

Technology Process of cis-Tranilast

There total 9 articles about cis-Tranilast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 53947-84-5
2-[(2-carboxyacetyl)amino]benzoic acid

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 53902-12-8,70806-55-2,91920-58-0
N-(3,4-dimethoxycinnamoyl)anthranilic acid

Guidance literature:: 2-[(2-carboxyacetyl)amino]benzoic acid; 3,4-dimethoxy-benzaldehyde; With piperidine; In toluene; for 3h; Reflux; Dean-Stark;

With methanol; In water; at 40 ℃;

With hydrogenchloride; In water;
DOI:10.1016/j.ejmech.2019.02.074