L-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[3,2-d]pyrimidin-6-yl) methyl]nitrosoamino]benzoyl]-, diethyl ester, (R)-

Base Information

• Chemical Name: L-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[3,2-d]pyrimidin-6-yl) methyl]nitrosoamino]benzoyl]-, diethyl ester, (R)-
• CAS No.: 92007-93-7
• Molecular Formula: C₂₄H₃₁N₇O₇
• Molecular Weight: 529.553
• Mol file: 92007-93-7.mol

Synonyms:

Chemical Property of L-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[3,2-d]pyrimidin-6-yl) methyl]nitrosoamino]benzoyl]-, diethyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[3,2-d]pyrimidin-6-yl) methyl]nitrosoamino]benzoyl]-, diethyl ester, (R)-

There total 2 articles about L-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[3,2-d]pyrimidin-6-yl) methyl]nitrosoamino]benzoyl]-, diethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

diethyl N10-nitroso-8-deazafolate (82855-87-6) → diethyl 5,6,7,8-tetrahydro-8-deazafolate (82855-85-4,92007-90-4,92007-91-5) + diethyl N10-nitroso-5,6,7,8-tetrahydro-8-deazafolate (82855-88-7,92007-92-6,92007-93-7)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; In ethanol;

DOI:10.1016/S0040-4039(00)87125-7

Reference yield:

diethyl 8-deazafolate (76807-65-3) → diethyl N10-nitroso-5,6,7,8-tetrahydro-8-deazafolate (82855-88-7,92007-92-6,92007-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaNO₂ / aq. HCl / 0 - 5 °C

2: 72 percent / 0.1 N HCl / Adams catalyst / ethanol

With hydrogenchloride; sodium nitrite; platinum(IV) oxide; In hydrogenchloride; ethanol;

DOI:10.1016/S0040-4039(00)87125-7

Reference yield:

diethyl N10-nitroso-5,6,7,8-tetrahydro-8-deazafolate (82855-88-7,92007-92-6,92007-93-7) + 3',5'-di-O-acetyl-5-bromomethyl-2'-deoxyuridine (58589-18-7) → C38H47N9O14 (82855-89-8,92007-96-0,92007-97-1)

Guidance literature:

DOI:10.1016/S0040-4039(00)87125-7

upstream raw materials:

diethyl N¹⁰-nitroso-8-deazafolate

diethyl 8-deazafolate

Downstream raw materials:

C₃₈H₄₇N₉O₁₄