4-[4-(BENZYLOXY)BENZOYL]MORPHOLINE

Base Information

• Chemical Name: 4-[4-(BENZYLOXY)BENZOYL]MORPHOLINE
• CAS No.: 92012-45-8
• Molecular Formula: C18H19NO3
• Molecular Weight: 297.354
• Mol file: 92012-45-8.mol

Synonyms:(4-Benzyloxy-phenyl)-morpholin-4-yl-methanone;

Chemical Property of 4-[4-(BENZYLOXY)BENZOYL]MORPHOLINE

Chemical Property:

• Melting Point: 72 °C
• PSA: 38.77000
• LogP: 2.67590

Purity/Quality:

4-[4-(benzyloxy)benzoyl]morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(BENZYLOXY)BENZOYL]MORPHOLINE

There total 3 articles about 4-[4-(BENZYLOXY)BENZOYL]MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

morpholine (110-91-8,99108-56-2) + p-benzyloxybenzaldehyde (4397-53-9) → <4-(Benzyloxy)benzoyl>morpholide (92012-45-8)

Guidance literature:

With sodium iodide; In water; acetonitrile; at 20 ℃; for 3h; Electrochemical reaction;

DOI:10.1016/j.tetlet.2021.153017

Reference yield:

morpholine (110-91-8,99108-56-2) + 4-(benzyloxy)benzoic acid chloride (1486-50-6) → <4-(Benzyloxy)benzoyl>morpholide (92012-45-8)

Guidance literature:

With triethylamine; In toluene; for 1h; Yield given;

DOI:10.1021/jo00196a020

Reference yield:

benzyl bromide (100-39-0) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → <4-(Benzyloxy)benzoyl>morpholide (92012-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 1 h / 20 °C

2: sodium iodide / acetonitrile; water / 3 h / 20 °C / Electrochemical reaction

With caesium carbonate; sodium iodide; In water; acetonitrile;

DOI:10.1016/j.tetlet.2021.153017

upstream raw materials:

morpholine

4-(benzyloxy)benzoic acid chloride

p-benzyloxybenzaldehyde

benzyl bromide

Downstream raw materials:

2-<4-(Benzyloxy)benzoyl>pyrrole

cis-1-(tert-Butoxycarbonyl)-2-<4-(benzyloxy)benzoyl>-5-benzylpyrrolidine

trans-1-(tert-Butoxycarbonyl)-2-<4-(benzyloxy)benzoyl>-5-benzylpyrrolidine

2-<4-(Benzyloxy)benzoyl>-5-benzylpyrrolidine trifluoroacetic acid salt