(3S,5R)-5-Phenyl-3-(prop-2-en-1-yl)-3-(trifluoromethyl)morpholin-2-one

Base Information

Chemical Name:(3S,5R)-5-Phenyl-3-(prop-2-en-1-yl)-3-(trifluoromethyl)morpholin-2-one
CAS No.:921224-77-3
Molecular Formula:C14H14F3NO2
Molecular Weight:285.266
Hs Code.:
DSSTox Substance ID:DTXSID20580435
Nikkaji Number:J2.404.746F
Wikidata:Q82471271

Synonyms:(3S,5R)-5-Phenyl-3-(prop-2-en-1-yl)-3-(trifluoromethyl)morpholin-2-one;921224-77-3;DTXSID20580435;VCQGJGJQASTEJM-AAEUAGOBSA-N

Suppliers and Price of (3S,5R)-5-Phenyl-3-(prop-2-en-1-yl)-3-(trifluoromethyl)morpholin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (3S,5R)-5-Phenyl-3-(prop-2-en-1-yl)-3-(trifluoromethyl)morpholin-2-one

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:285.09766318
Heavy Atom Count:20
Complexity:377

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CCC1(C(=O)OCC(N1)C2=CC=CC=C2)C(F)(F)F
Isomeric SMILES:C=CC[C@]1(C(=O)OC[C@H](N1)C2=CC=CC=C2)C(F)(F)F

Technology Process of (3S,5R)-5-Phenyl-3-(prop-2-en-1-yl)-3-(trifluoromethyl)morpholin-2-one

There total 6 articles about (3S,5R)-5-Phenyl-3-(prop-2-en-1-yl)-3-(trifluoromethyl)morpholin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1094092-25-7
(4R)-2-ethoxycarbonyl-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

: 762-72-1
allyl-trimethyl-silane

: (3R,5R)-3-allyl-5-phenyl-3-(trifluoromethyl)morpholin-2-one

: 921224-77-3
(3S,5R)-3-allyl-3-trifluoromethyl-5-phenylmorpholin-2-one

Guidance literature:: (4R)-2-ethoxycarbonyl-2-trifluoromethyl-4-phenyl-1,3-oxazolidine; allyl-trimethyl-silane; With boron trifluoride diethyl etherate;

With 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In toluene; optical yield given as %de; Reflux;
DOI:10.1016/j.jfluchem.2008.07.019

Reference yield:

: 921224-73-9
(1R)-N-[(E)-1-ethoxycarbonyl-2,2,2-trifluoroethylidene]-(2-tert-butyldimethylsilyloxy-1-phenylethyl)amine

: 762-72-1
allyl-trimethyl-silane

: (3R,5R)-3-allyl-5-phenyl-3-(trifluoromethyl)morpholin-2-one

: 921224-77-3
(3S,5R)-3-allyl-3-trifluoromethyl-5-phenylmorpholin-2-one

Guidance literature:: (1R)-N-[(E)-1-ethoxycarbonyl-2,2,2-trifluoroethylidene]-(2-tert-butyldimethylsilyloxy-1-phenylethyl)amine; allyl-trimethyl-silane; With tin(IV) chloride; In dichloromethane; at 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol062593+

Reference yield:

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 56613-80-0
D-2-phenylglycinol

: 762-72-1
allyl-trimethyl-silane

: (3R,5R)-3-allyl-5-phenyl-3-(trifluoromethyl)morpholin-2-one

: 921224-77-3
(3S,5R)-3-allyl-3-trifluoromethyl-5-phenylmorpholin-2-one

Guidance literature:: ethyl-3,3,3-trifluoropyruvate; D-2-phenylglycinol; With pyridinium p-toluenesulfonate; In toluene; Heating;

allyl-trimethyl-silane; With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃;

With toluene-4-sulfonic acid; In toluene; for 24h; Heating;
DOI:10.1021/ol062593+