6-[(4-Chlorophenyl)(diphenyl)methoxy]hexan-1-ol

Base Information

• Chemical Name: 6-[(4-Chlorophenyl)(diphenyl)methoxy]hexan-1-ol
• CAS No.: 921588-01-4
• Molecular Formula: C25H27ClO2
• Molecular Weight: 394.941
• DSSTox Substance ID: DTXSID30582667
• Wikidata: Q82474163
• Mol file: 921588-01-4.mol

Synonyms:921588-01-4;6-[(4-Chlorophenyl)(diphenyl)methoxy]hexan-1-ol;DTXSID30582667

Chemical Property of 6-[(4-Chlorophenyl)(diphenyl)methoxy]hexan-1-ol

Chemical Property:

• XLogP3: 6.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 10
• Exact Mass: 394.1699578
• Heavy Atom Count: 28
• Complexity: 389

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)Cl)OCCCCCCO

Technology Process of 6-[(4-Chlorophenyl)(diphenyl)methoxy]hexan-1-ol

There total 1 articles about 6-[(4-Chlorophenyl)(diphenyl)methoxy]hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,6-hexanediol (629-11-8) + 4-chlorotrityl chloride (27023-37-6) → 6-[1-(4-chlorophenyl)-1,1-(diphenyl)methoxy]hexanol (921588-01-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jm0610550

Reference yield:

6-[1-(4-chlorophenyl)-1,1-(diphenyl)methoxy]hexanol (921588-01-4) + N-3-benzoylthymine (4330-20-5) → 3-benzoyl-1-{6-[(4-chloro-phenyl)-diphenyl-methoxy]-hexyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:

With PS-Ph₃P; di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm0610550

Reference yield:

6-[1-(4-chlorophenyl)-1,1-(diphenyl)methoxy]hexanol (921588-01-4) → 1-[6-[1-(4-chlorophenyl)-1,1-(diphenyl)methoxy]hexyl]thymine

Guidance literature:

Multi-step reaction with 2 steps

1: PS-Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2: aq. NaOH / dioxane

With sodium hydroxide; PS-Ph₃P; di-isopropyl azodicarboxylate; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction;

DOI:10.1021/jm0610550

upstream raw materials:

1,6-hexanediol

4-chlorotrityl chloride