1-(5-AMINO-2-PYRIDINYL)-3-(R)-PYRROLIDINOL

Base Information

• Chemical Name: 1-(5-AMINO-2-PYRIDINYL)-3-(R)-PYRROLIDINOL
• CAS No.: 921592-86-1
• Molecular Formula: C9H13N3O
• Molecular Weight: 179.222
• Mol file: 921592-86-1.mol

Synonyms:(R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-ol;3-Pyrrolidinol,1-(5-amino-2-pyridinyl)-,(3R);1-(5-Amino-2-pyridinyl)-3-(R)-pyrrolidinol;

Chemical Property of 1-(5-AMINO-2-PYRIDINYL)-3-(R)-PYRROLIDINOL

Chemical Property:

• PSA: 62.38000
• LogP: 0.88100

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Amino-2-pyridinyl)-3-(R)-pyrrolidinol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-AMINO-2-PYRIDINYL)-3-(R)-PYRROLIDINOL

There total 3 articles about 1-(5-AMINO-2-PYRIDINYL)-3-(R)-PYRROLIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-1-(5-nitropyridin-2-yl)pyrrolidin-3-ol (921592-85-0) → (R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-ol (921592-86-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 23 ℃; for 1h;

Reference yield:

5-nitro-2-hydroxypyridine (5418-51-9) → (R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-ol (921592-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate; phosphorus pentachloride / 16 h / 60 °C

2: 18-crown-6 ether; potassium carbonate / acetonitrile / Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 23 °C

With 18-crown-6 ether; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; trichlorophosphate; In methanol; acetonitrile;

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → (R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-ol (921592-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 18-crown-6 ether; potassium carbonate / acetonitrile / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 23 °C

With 18-crown-6 ether; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; acetonitrile;

upstream raw materials:

(R)-1-(5-nitropyridin-2-yl)pyrrolidin-3-ol

5-nitro-2-hydroxypyridine

2-chloro-5-nitropyridine

Downstream raw materials:

(R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

(R)-phenyl 6-(3-hydroxypyrrolidin-1-yl)pyridin-3-ylcarbamate

Refernces

• 1、 -. "Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands". Paragraph 0991. . Retrieved 2013/03/26.