(R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

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Chemical Name:(R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea
CAS No.:1419600-68-2
Molecular Formula:C₂₁H₂₀ClF₃N₆O₂
Molecular Weight:480.877
Hs Code.:

Synonyms:(R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

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Chemical Property of (R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

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Technology Process of (R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

There total 11 articles about (R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1254713-79-5
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

: 1419604-07-1
(R)-phenyl 6-(3-hydroxypyrrolidin-1-yl)pyridin-3-ylcarbamate

: 1419600-68-2
(R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 23 ℃;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1419600-68-2
(R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 5 h / -5 - 0 °C

2.1: ethanol / 5 h / Reflux

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

4.1: triethylamine / toluene / 20 h / 80 °C

5.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

6.1: triethylamine / dimethyl sulfoxide / 23 °C

With hydrogenchloride; N-chloro-succinimide; ammonia; hydrogen; triethylamine; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419600-68-2
(R)-1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 3 h / Reflux

2: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

3: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

4: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5: triethylamine / dimethyl sulfoxide / 23 °C

With ammonia; hydrogen; triethylamine; potassium iodide; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dimethyl sulfoxide; acetonitrile;