benzyl 4-bromophenylcarbamate

Base Information

• Chemical Name: benzyl 4-bromophenylcarbamate
• CAS No.: 92159-87-0
• Molecular Formula: C14H12BrNO2
• Molecular Weight: 306.159
• Mol file: 92159-87-0.mol

Synonyms:4-bromo-C6H4As(O)(OH)2;(4-bromphenyl)carbamic acid benzyl ester;(4-bromo-phenyl)-carbamic acid benzyl ester;4-(Bromophenyl)arsonic acid;benzyl 4-bromophenylcarbamate;N-(carbobenzyloxy)-4-bromaniline;benzyl N-(4-bromophenyl)carbamate;(4-Brom-phenyl)-carbamidsaeure-benzylester;4-Brom-benzol-arsonsaeure-(1);(4-Brom-phenyl)-arsonsaeure;

Chemical Property of benzyl 4-bromophenylcarbamate

Chemical Property:

• Melting Point: 121-123 °C
• Boiling Point: 367.8±35.0 °C(Predicted)
• PKA: 12.93±0.70(Predicted)
• PSA: 38.33000
• Density: 1.487±0.06 g/cm3(Predicted)
• LogP: 4.27080

Purity/Quality:

98%min ^*data from raw suppliers

Benzyl 4-bromophenylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl 4-bromophenylcarbamate

There total 15 articles about benzyl 4-bromophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl chloroformate (501-53-1,94274-21-2) + 4-bromo-aniline (106-40-1) → benzyl (4-bromophenyl)carbamate (92159-87-0)

Guidance literature:

In PEG-600; at 20 ℃; for 0.166667h; chemoselective reaction;

DOI:10.1016/j.cclet.2012.05.012

Reference yield: 95.0%

4-Bromobenzoic acid (586-76-5) + benzyl alcohol (100-51-6,185532-71-2) → benzyl (4-bromophenyl)carbamate (92159-87-0)

Guidance literature:

With trimethylsilylazide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; Reflux;

DOI:10.1055/s-0030-1259964

Reference yield: 90.0%

O-benzyl carbamate (621-84-1) + 1,4-bromoiodobenzene (589-87-7) → benzyl (4-bromophenyl)carbamate (92159-87-0)

Guidance literature:

With copper(l) iodide; ethylenediamine; sodium t-butanolate; In toluene; at 100 ℃; for 5h;

DOI:10.1007/s10562-017-2277-0

upstream raw materials:

benzyl chloroformate

4-bromo-aniline

p-bromobenzoyl azide

benzyl alcohol

Downstream raw materials:

benzyl ((4-(1,4-dioxaspiro)[4.5] dec-7-en-8-yl)phenyl)carbamate

(4-(N-benzyloxycarbonyl-N-methylamino)phenyl)phosphinic acid

C₂₃H₂₈NPO₈

iodomethylbenzene

Refernces

• 1、 Fan, Jiali,Wei, Qiancheng,Zhu, Ershu,Gao, Jing,Cheng, Xiamin,Lu, Yongna,Loh, Teck-Peng. "Visible light-induced mono-bromination of arenes with BrCCl3". supporting information. p. 5977 - 5980. Retrieved 2021/06/18.
• 2、 -. "Pyrazolone-fused pyrimidine compound as well as preparation method and application thereof". Paragraph 0537-0540. . Retrieved 2021/01/11.