Chemical Property of Dihydromyricetin
Chemical Property:
- Vapor Pressure:1.16E-25mmHg at 25°C
- Melting Point:239-241 °C
- Refractive Index:1.798
- Boiling Point:780.7 °C at 760 mmHg
- PKA:7.38±0.60(Predicted)
- Flash Point:296.7 °C
- PSA：147.68000
- Density:1.808 g/cm3
- LogP:0.89190
- Storage Temp.:?20°C
- Solubility.:DMSO: ≥5mg/mL (warmed)
- XLogP3:1.1
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:1
- Exact Mass:320.05321734
- Heavy Atom Count:23
- Complexity:445
- Purity/Quality:
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≥98% *data from raw suppliers
Ampeloptin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O
- Isomeric SMILES:C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O
- Recent ClinicalTrials:Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease
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Description
Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound, which is found in large quantities in Asian plant species. One of them – Hovenia dulcis – is known for centuries in traditional Chinese medicine as a cure for alcohol poisoning and hangover (Liang et al. 2014). DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties.Dihydromyricetin had beneficial effects on health such as antimicrobial, anti-inflammatory,antioxidative, anticancer, lipid and glucose metabolism-regulatory activities，and cell death-mediating without or with minimum adverse effects on normal cells. And most importantly, DHM has been shown to provide significant hepatoprotective effects. Its positive influence on alcohol-induced and other liver diseases was suggested in the study of acute liver failure (Liu et al. 2017).
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Uses
Dihydromyricetin has been used to study its effect on adipogenesis and glucose uptake in differentiated 3T3-L1 pre-adipocytes. It has also been used to study its antitumor activity against liver cancer cells.
