N-Acetyl-DL-glutamic acid

Base Information

• Chemical Name: N-Acetyl-DL-glutamic acid
• CAS No.: 5817-08-3
• Deprecated CAS: 2618834-79-8
• Molecular Formula: C7H11NO5
• Molecular Weight: 189.168
• European Community (EC) Number: 227-388-6
• NSC Number: 10854
• DSSTox Substance ID: DTXSID00859595
• Wikidata: Q307661
• Metabolomics Workbench ID: 126919
• ChEMBL ID: CHEMBL2142890
• Mol file: 5817-08-3.mol

Synonyms:2-acetamidopentanedioic acid;5817-08-3;N-Acetyl-DL-glutamic acid;DL-Acetylglutamic acid;Acetyl-DL-glutamic acid;N-Acetyl-DL-glutamicAcid;acetyl-glu;MFCD00002802;N-acetyl-dl-glutamic acid crystalline;ACEGLUMATE;Maybridge1_002521;2-acetamidopentanedioicacid;MLS002207281;DivK1c_001273;DL-Glutamic acid, N-acetyl-;SCHEMBL198970;CHEMBL2142890;HMS548K13;DTXSID00859595;CHEBI:172431;NSC10854;EINECS 227-388-6;BBL012280;BTB 13546;MFCD00063195;NSC 10854;NSC-10854;STK803143;AKOS005614049;AB02539;CS-W015958;CDS1_000233;N-Acetylglutamic acid (Ac-DL-Glu-OH);NCGC00094839-01;NCGC00094839-02;AS-59424;SMR001306797;SY017890;AM20100420;FT-0629833;FT-0635867;FT-0659480;FT-0695847;D95099;EN300-7397724;A831768;Q307661;102F8DF7-7489-46B2-80D2-B34561C2DF56

Chemical Property of N-Acetyl-DL-glutamic acid

Chemical Property:

• Melting Point: 176-180 °C
• Boiling Point: 495.9°C at 760mmHg
• PKA: 3.45±0.10(Predicted)
• Flash Point: 253.7°C
• PSA: 103.70000
• Density: 1.354g/cm³
• LogP: -0.16860
• Storage Temp.: 2-8°C
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 189.06372245
• Heavy Atom Count: 13
• Complexity: 225

Purity/Quality:

99% ^*data from raw suppliers

2-Acetamidopentanedioicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC(CCC(=O)O)C(=O)O

Technology Process of N-Acetyl-DL-glutamic acid

There total 9 articles about N-Acetyl-DL-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Glutamic acid (617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + acetic anhydride (108-24-7) → Acetyl-D,L-glutaminsaeure (5817-08-3)

Guidance literature:

With sodium hydroxide; l(-)-acetylglutamic acid;

Reference yield:

Ketene (463-51-4) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → Acetyl-D,L-glutaminsaeure (5817-08-3)

Guidance literature:

With sodium hydroxide;

Reference yield:

sodium diethylmalonate (996-82-7) → Acetyl-D,L-glutaminsaeure (5817-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / und Kochen des Reaktionsprodukts mit 25prozentiger Salzsaeure

2: aqueous NaOH-solution

With sodium hydroxide; benzene;

upstream raw materials:

Ketene

L-glutamic acid

1-methyl-4-nitrosobenzene

N-(2-cyclopentenyl)ethanamide

Downstream raw materials:

N-acetyl-glutamine

(R)-2-amino-5-methoxy-5-oxopentanoic acid

N-(tert-butyloxycarbonyl)-δ-benzyl<α-2H>aminoadipic acid methyl ester

N-(tert-butyloxycarbonyl)-γ-benzyl<α-2H>glutamic acid methyl ester

Refernces

• 1、 -. "RENAL-SELECTIVE BIPHENYLALKYL 1H-SUBSTITUTED-1,2,4-TRIAZOLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF HYPERTENSION". . . Retrieved 2008/06/13.