Cyclopentanol, 4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2,3-bis(phenylmethoxy)-, (1S,2S,3R,4R)-

Base Information

Chemical Name:Cyclopentanol, 4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2,3-bis(phenylmethoxy)-, (1S,2S,3R,4R)-
CAS No.:921771-01-9
Molecular Formula:C27H34O5
Molecular Weight:438.564
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopentanol, 4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2,3-bis(phenylmethoxy)-, (1S,2S,3R,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopentanol, 4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2,3-bis(phenylmethoxy)-, (1S,2S,3R,4R)-

There total 12 articles about Cyclopentanol, 4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2,3-bis(phenylmethoxy)-, (1S,2S,3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 921771-00-8
(2R,3R,4R)-2,3-bis(benzyloxy)-4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]cyclopentanone

: 921771-01-9
(1S,2S,3R,4R)-2,3-bis(benzyloxy)-4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]cyclopentanol

: 921770-99-2
(1R,2S,3R,4R)-2,3-bis(benzyloxy)-4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]cyclopentanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -60 ℃; for 1h;
DOI:10.1021/jo061717t

Reference yield:

: 763105-46-0
(S)-(S)-4-(1,4-Dioxa-spiro[4.5]dec-2-yl)-cyclopent-2-enol

: 921771-01-9
(1S,2S,3R,4R)-2,3-bis(benzyloxy)-4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]cyclopentanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 96 percent / Jones reagent / acetone / 0.5 h / 0 °C

2.1: 79 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

3.1: 96 percent / triethylamine; DMAP; imidazole / CH₂Cl₂ / 18 h / 20 °C

4.1: 96 percent / N-methyl-morpholine N-oxide monohydrate / OsO₄ / acetone; H₂O / 14 h / 20 °C

5.1: NaH / tetrahydrofuran / 2 h / 20 °C

5.2: 91 percent / HMPA / tetrahydrofuran / 12 h / 20 °C

6.1: 90 percent / n-Bu₄N(+)F(-)*3H₂O / tetrahydrofuran / 2 h / 20 °C

7.1: 87 percent / Jones reagent / acetone / 0.5 h / 0 °C

8.1: 60 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; jones reagent; tetrabutyl ammonium fluoride; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo061717t

Reference yield:

: 921770-86-7
(4S)-4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]cyclopent-2-en-1-one

: 921771-01-9
(1S,2S,3R,4R)-2,3-bis(benzyloxy)-4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]cyclopentanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 79 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

2.1: 96 percent / triethylamine; DMAP; imidazole / CH₂Cl₂ / 18 h / 20 °C

3.1: 96 percent / N-methyl-morpholine N-oxide monohydrate / OsO₄ / acetone; H₂O / 14 h / 20 °C

4.1: NaH / tetrahydrofuran / 2 h / 20 °C

4.2: 91 percent / HMPA / tetrahydrofuran / 12 h / 20 °C

5.1: 90 percent / n-Bu₄N(+)F(-)*3H₂O / tetrahydrofuran / 2 h / 20 °C

6.1: 87 percent / Jones reagent / acetone / 0.5 h / 0 °C

7.1: 60 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; jones reagent; tetrabutyl ammonium fluoride; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo061717t