3-Piperidinecarboxylic acid, 1-[4-[[4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3- methylbutoxy)phenyl](2,2-dimethylpropyl)amino]-1,4-dioxobutyl]-, ethyl ester, (3S)-

Base Information

Chemical Name:3-Piperidinecarboxylic acid, 1-[4-[[4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3- methylbutoxy)phenyl](2,2-dimethylpropyl)amino]-1,4-dioxobutyl]-, ethyl ester, (3S)-
CAS No.:922161-83-9
Molecular Formula:C36H51ClN2O8
Molecular Weight:675.263
Hs Code.:

3-Piperidinecarboxylic acid,
1-[4-[[4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-
methylbutoxy)phenyl](2,2-dimethylpropyl)amino]-1,4-dioxobutyl]-, ethyl
ester, (3S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Piperidinecarboxylic acid, 1-[4-[[4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3- methylbutoxy)phenyl](2,2-dimethylpropyl)amino]-1,4-dioxobutyl]-, ethyl ester, (3S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Piperidinecarboxylic acid, 1-[4-[[4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3- methylbutoxy)phenyl](2,2-dimethylpropyl)amino]-1,4-dioxobutyl]-, ethyl ester, (3S)-

There total 12 articles about 3-Piperidinecarboxylic acid, 1-[4-[[4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3- methylbutoxy)phenyl](2,2-dimethylpropyl)amino]-1,4-dioxobutyl]-, ethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 922161-82-8
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 922161-83-9
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 2568-33-4
3-methyl-butane-1,3-diol

: 922161-83-9
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 7.5 h / 20 °C / Cooling with ice

2.1: sodium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C

3.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.5 h / -78 - 20 °C

3.2: 1.5 h / -78 - -50 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 4 h / 0 - 50 °C

4.2: 0.08 h

5.1: Chiralcel OD column / hexane; isopropyl alcohol / 20 °C / Resolution of racemate; HPLC conditions

6.1: sodium hydrogencarbonate / dichloromethane / 1 h / 20 °C / Cooling with ice

7.1: water; potassium carbonate / methanol / 2.5 h / 60 °C

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2.5 h / 20 °C

With water; sec.-butyllithium; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 922163-03-9
4-(5-chloro-2-[(2,2-dimethylpropyl)amino]-3-[hydroxy(2-methoxyphenyl)methyl]phenoxy)-2-methylbutan-2-ol

: 922161-83-9
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Chiralcel OD column / hexane; isopropyl alcohol / 20 °C / Resolution of racemate; HPLC conditions

2: sodium hydrogencarbonate / dichloromethane / 1 h / 20 °C / Cooling with ice

3: water; potassium carbonate / methanol / 2.5 h / 60 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2.5 h / 20 °C

With water; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2011.07.007