37675-18-6

Basic information

• Product Name: Ethyl (3S)-piperidine-3-carboxylate
• Synonyms: (S)-(+)-ETHYL NIPECOTATE;(S)-ETHYL-NIPECOTATE;(S)-ETHYL PIPERIDINE-3-CARBOXYLATE;(S)-(+)-NIPECOTIC ACID ETHYL ESTER;(S)-NIPECOTIC ACID ETHYL ESTER;(S)-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER;(S)-(+)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER;ETHYL (S)-(+)-NIPECOTATE
• CAS NO: 37675-18-6
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.21
• EINECS: 2017-001-1
• Product Categories: Nitrogen cyclic compounds;Piperidine;Heterocyclic Compounds;Chiral Building Blocks;Esters (Chiral);Synthetic Organic Chemistry
• Mol File: 37675-18-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 102-104 °C/7 mmHg(lit.)
• Flash Point: 77 °C
• Appearance: liquid
• Density: 1,02 g/cm3
• Vapor Pressure: 0.042mmHg at 25°C
• Refractive Index: n20/D 1.471
• Storage Temp.: Refrigerator
• PKA: 9.35±0.10(Predicted)
• Sensitive: Light, Air & Moisture Sensitive
• CAS DataBase Reference: Ethyl (3S)-piperidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (3S)-piperidine-3-carboxylate(37675-18-6)
• EPA Substance Registry System: Ethyl (3S)-piperidine-3-carboxylate(37675-18-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39-36
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 37675-18-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

Reactant for synthesis of:DPP-4 inhibitorsJAK2 inhibitorsSerotonin and noradrenaline reuptake inhibitorsHuman tryptase inhibitorsAnti-thrombotic nicecotamidesReactive for oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization

InChI:InChI=1/C8H15NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h7,9H,2-6H2,1H3/t7-/m0/s1

Synthetic route

(S)-ethyl nipecotate (S,S)-hydrogen tartrate → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
With sodium hydroxide In water at 0℃;	89%
With sodium hydroxide In water at 0℃;	89%
In water at 0℃; pH=13; Decomposition;	65%
With sodium hydroxide In water

C4H6O6*C8H15NO2 (183316-65-6) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
With sodium hydroxide In water	89%

Ethyl nipecotate (71962-74-8) → (R)-ethyl nipecotate (25137-01-3) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
Stage #1: Ethyl nipecotate With L-Tartaric acid Stage #2: With potassium carbonate	A 20% B n/a
With L-Tartaric acid In ethanol; acetone at 20℃; resolution;
With L-Tartaric acid In ethanol Resolution of racemate; optical yield given as %ee;
With L-Tartaric acid Resolution of racemate;

Ethyl nipecotate (71962-74-8) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
With D-tartaric acid
Resolution of racemate;

(3S)-Piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester (174699-11-7) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
With hydrogen; acetic acid; palladium on activated charcoal In ethanol for 3h;

(4R)-3-({(3S)-1-[(benzyloxy)carbonyl]piperidin-3-yl}carbonyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one (868632-22-8) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 2: rac. camphersulfonic acid / 15 h / Heating 3: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

5-bromovaleroyl chloride (4509-90-4) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions

Yield

Multi-step reaction with 6 steps 1.1: BuLi / tetrahydrofuran / 0.17 h / -30 °C 1.2: 87 percent / tetrahydrofuran / 2 h / 0 °C 2.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 2.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 3.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 4.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 5.1: rac. camphersulfonic acid / 15 h / Heating 6.1: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

(3S)-1-phenylmethoxycarbonylpiperidine-3-carboxylic acid (88466-74-4) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: rac. camphersulfonic acid / 15 h / Heating 2: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

(4R)-3-(5-bromo-1-oxopentyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one (637337-43-0) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 1.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 2.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 3.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 4.1: rac. camphersulfonic acid / 15 h / Heating 5.1: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

(4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-5-bromo-1-oxopentyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one (637337-59-8) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 2: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 3: rac. camphersulfonic acid / 15 h / Heating 4: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

3-pyridinecarboxylic acid ethyl ester (614-18-6) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: Raney nickel; dioxane / 165 °C / 110326 - 220652 Torr / Hydrogenation 2: Dg-tartaric acid View Scheme

salt of (D)-2-(4-hydroxyphenoxy)propionic acid with ethyl 3-piperidinecarboxylate → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
With sodium carbonate In diethyl ether at 20℃; for 2h;	1.15 g

ethanol (64-17-5) + (S)-nipecotic acid (498-95-3, 25137-00-2, 59045-82-8, 60252-41-7) → (S)-(+)-nipecotic acid ethyl ester (37675-18-6)

Conditions	Yield
With thionyl chloride at 100℃; for 6h; Inert atmosphere;

chloroformic acid ethyl ester (541-41-3) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl N-carbethoxy-piperidine-3S-carboxylate (1346514-04-2)

Conditions	Yield
With 4-methyl-morpholine In chloroform at 0 - 20℃;	100%

(R)-2-fluoro-4-(1-hydroxybutyl)benzoic acid + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-1-(2-fluoro-4-((1R)-1-hydroxybutyl)benzoyl)piperidine-3-carboxylic acid ethyl ester

Conditions	Yield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;	99%

acetic anhydride (108-24-7) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-nipecotic acid ethyl ester

Conditions	Yield
In dichloromethane at 20℃; for 24h;	99%

(S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-(hydroxymethyl)piperidine (4606-65-9, 37675-20-0, 136982-27-9, 144539-77-5)

Conditions	Yield
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 0.333333h; Heating / reflux; Stage #2: With sodium sulfate In tetrahydrofuran; diethyl ether; water	98%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux;	98%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux;	98%
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 3h; Stage #2: With potassium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 15h;
With sodium tetrahydroborate; zinc(II) chloride In tetrahydrofuran at 50 - 66℃; for 4.5h; Inert atmosphere;

isopentanoyl chloride (108-12-3) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-ethyl 1-(3-methylbutanoyl)piperidine-3-carboxylate (1554631-89-8)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 6h;	97.5%

9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid (1121526-82-6) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (3S)-ethyl 1-(9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carbonyl)piperidine-3-carboxylate (1121527-59-0)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 1h;	97%

2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride (952674-99-6) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)piperidine-3-carboxylate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h;	96%
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h;	96%

(S)-(+)-nipecotic acid ethyl ester (37675-18-6) + (S)-2-(benzyloxycarbonylaminomethyl)-3-phenylpropanoic acid (261174-46-3) → Cbz-(S)β2hPhe-(S)β2hPro-OEt (764704-88-3)

Conditions	Yield
With 4-methyl-morpholine; HATU In dichloromethane at 0 - 25℃;	95%

(S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-piperidine-3-carboxylic acid ethyl ester hydrochloride

Conditions	Yield
With hydrogenchloride In water; toluene at 60℃; Cooling;	95%
Multi-step reaction with 3 steps 1: 74 percent / CH2Cl2 / 16 h / 20 °C 2: 90 percent / LiOH / methanol; H2O / 72 h / 20 °C 3: HCl / 1.5 h / 110 °C View Scheme

formic acid (64-18-6) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → C9H17NO2

Conditions	Yield
In methanol at 0℃; for 6h; Reflux;	93.4%

4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid (922161-60-2) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-(4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate (922161-61-3)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	92%

N-(3,5-dichlorophenyl)picolinamide (879824-11-0) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → C20H21Cl2N3O3

Conditions	Yield
With [bis(acetoxy)iodo]benzene; copper(II) acetate monohydrate; magnesium chloride In 1,4-dioxane at 20℃; for 4h; Inert atmosphere;	92%

3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid (937054-53-0) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)propanoyl)-3-piperidinecarboxylate (937055-14-6)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	91%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 14.6h;

4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)-amino]-4-oxobutanoic acid (922161-64-6) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate (1334531-23-5)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	88%

2,6-Dichloropyrimidine (3934-20-1) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-ethyl 1-(2-chloropyrimidin-4-yl)piperidine-3-carboxylate (1347758-03-5)

Conditions	Yield
With triethylamine In ethanol at 0 - 23℃; for 18h; Inert atmosphere;	88%

formic acid (64-18-6) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-formylpiperidine-3-carboxylate

Conditions	Yield
In toluene for 4.5h; Reflux; Dean-Stark;	88%

formaldehyd (50-00-0) + ethanol (64-17-5) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl 1-(ethoxymethyl)piperidine-3-carboxylate

Conditions	Yield
Stage #1: ethanol; (S)-(+)-nipecotic acid ethyl ester With potassium carbonate at 0℃; for 0.25h; Inert atmosphere; Stage #2: formaldehyd at 25℃; for 6h; Inert atmosphere;	88%

di-tert-butyl dicarbonate (24424-99-5) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate (191599-51-6)

Conditions	Yield
In dichloromethane	87%
With triethylamine In dichloromethane at 20℃; for 3h;	87%
With triethylamine In dichloromethane at 20℃; for 3h;	87%

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (88495-54-9) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → Boc-(S)-β2-HPro-(S)-β2-HPro-OEt (253790-54-4)

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In chloroform at 0℃; for 16h; Acylation; peptide coupling;	87%

4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid (922161-76-0) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-(4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate (922161-77-1)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	87%

3-chloro-2-methylbenzoic acid (7499-08-3) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-ethyl 1-(3-chloro-2-methylbenzoyl)piperidine-3-carboxylate (1430424-36-4)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;	86%

(S)-(+)-nipecotic acid ethyl ester (37675-18-6) + tert-butyl 2-(3-bromophenoxy)-2-methylpropanoate (393186-07-7) → ethyl (S)-1-(3-((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)phenyl)piperidine-3-carboxylate

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In toluene at 80℃;	82%

4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid (922161-82-8) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate (922161-83-9)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	81%

2-bromo-4-fluoro-pyridine (357927-50-5) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → (S)-ethyl 1-(2-bromopyridin-4-yl)piperidine-3-carboxylate

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃;	81%
With potassium carbonate In dimethyl sulfoxide at 100℃;	81%

(S)-(+)-2-(4-cyanophenyl)oxirane (179694-33-8) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate (1265323-48-5)

Conditions	Yield
With dmap In isopropyl alcohol at 50℃; Inert atmosphere; stereospecific reaction;	80%
Stage #1: (S)-(+)-2-(4-cyanophenyl)oxirane; (S)-(+)-nipecotic acid ethyl ester In isopropyl alcohol at 55℃; for 4h; Inert atmosphere; Stage #2: With dmap In isopropyl alcohol at 50℃; for 12h;	72%

4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl 4-methylbenzenesulfonate (148319-31-7) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (S)-1-<4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl>-3-piperidinecarboxylate (148319-28-2)

Conditions	Yield
With potassium carbonate; potassium iodide In acetone for 44h; Ambient temperature;	79%

4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid (922160-87-0) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate (922160-92-7)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	74%

4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)-methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid (922161-43-1) + (S)-(+)-nipecotic acid ethyl ester (37675-18-6) → ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate (922161-44-2) + ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate (922161-44-2)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	A 7% B 74%

Upstream product

• 64-17-5 ethanol 
• 498-95-3 (S)-nipecotic acid 
• 183316-65-6 C₄H₆O₆*C₈H₁₅NO₂ 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 637337-59-8 (4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-5-bromo-1-oxopentyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 637337-43-0 (4R)-3-(5-bromo-1-oxopentyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 88466-74-4 (3S)-1-phenylmethoxycarbonylpiperidine-3-carboxylic acid 
• 4509-90-4 5-bromovaleroyl chloride 
• 868632-22-8 (4R)-3-({(3S)-1-[(benzyloxy)carbonyl]piperidin-3-yl}carbonyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 174699-11-7 (3S)-Piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester 
• 163343-71-3 (S)-ethyl nipecotate (S,S)-hydrogen tartrate 
• 71962-74-8 Ethyl nipecotate 

Downstream Products

• 498-95-3 (S)-nipecotic acid 
• 310455-01-7 ethyl N-benzylpiperidine-3-carboxylate 
• 4606-65-9 (S)-(hydroxymethyl)piperidine 
• 927206-84-6 ethyl (3S)-1-{[trans-4-(2,4-dichlorophenyl)-5-nitrocyclohex-1-en-1-yl]methyl}piperidine-3-carboxylate 
• 6874-86-8 (–)-castoramine 
• 764704-88-3 Cbz-(S)β²hPhe-(S)β²hPro-OEt 
• 191599-51-6 ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate 

Relevant articles and documents

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